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    NGF nerve growth factor [ Bos taurus (domestic cattle) ]

    Gene ID: 281350, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NGFprovided by VGNC
    Official Full Name
    nerve growth factorprovided by VGNC
    Primary source
    VGNC:VGNC:32061
    See related
    BGD:BT27488; Ensembl:ENSBTAG00000007446
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NGFB
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See NGF in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (27948630..28007003)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112445869 Neighboring gene dnaJ homolog subfamily A member 2-like Neighboring gene uncharacterized LOC132344854 Neighboring gene transfer RNA glutamic acid (anticodon UUC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization. Elduque C, et al. Cytogenet Cell Genet, 1997. PMID 9284944
    2. Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF. Meier R, et al. EMBO J, 1986 Jul. PMID 2427334, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nerve growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peripheral nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of collateral sprouting IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-nerve growth factor
    Names
    beta-NGF
    nerve growth factor, beta polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099362.1 → NP_001092832.1  beta-nerve growth factor precursor

      See identical proteins and their annotated locations for NP_001092832.1

      Status: PROVISIONAL

      Source sequence(s)
      BC146037
      UniProtKB/Swiss-Prot
      A6H6X9, O18969, P13600
      UniProtKB/TrEMBL
      A0A3Q1N6X2
      Conserved Domains (1) summary
      pfam00243
      Location:128 → 236
      NGF; Nerve growth factor family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27948630..28007003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881561.1 → XP_059737544.1  beta-nerve growth factor isoform X2

      UniProtKB/Swiss-Prot
      A6H6X9, O18969, P13600
      UniProtKB/TrEMBL
      A0A3Q1N6X2
      Related
      ENSBTAP00070048436.1, ENSBTAT00070079993.1

    2. XM_010803102.4 → XP_010801404.1  beta-nerve growth factor isoform X2

      See identical proteins and their annotated locations for XP_010801404.1

      UniProtKB/Swiss-Prot
      A6H6X9, O18969, P13600
      UniProtKB/TrEMBL
      A0A3Q1N6X2
      Related
      ENSBTAP00070048432.1, ENSBTAT00070079987.1
      Conserved Domains (1) summary
      pfam00243
      Location:128 → 236
      NGF; Nerve growth factor family

    3. XM_059881564.1 → XP_059737547.1  beta-nerve growth factor isoform X2

      UniProtKB/Swiss-Prot
      A6H6X9, O18969, P13600
      UniProtKB/TrEMBL
      A0A3Q1N6X2
      Related
      ENSBTAP00070048430.1, ENSBTAT00070079980.1

    4. XM_024984621.2 → XP_024840389.1  beta-nerve growth factor isoform X1

      UniProtKB/TrEMBL
      A0A3Q1N6X2, A0A452DI70
      Related
      ENSBTAP00070048429.1, ENSBTAT00070079976.1
      Conserved Domains (1) summary
      pfam00243
      Location:186 → 294
      NGF; Nerve growth factor family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13600.3 GenPept UniProtKB/Swiss-Prot:P13600

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials