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    ROCK2 Rho associated coiled-coil containing protein kinase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282041, updated on 30-Jan-2025

    Summary

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    Official Symbol
    ROCK2provided by VGNC
    Official Full Name
    Rho associated coiled-coil containing protein kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:34082
    See related
    EnsemblRapid:ENSBTAG00070006340
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ROCK-II
    Orthologs
    human mouse all
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    Genomic context

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    See ROCK2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (86489043..86617614)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene E2F transcription factor 6 Neighboring gene histone H4-like Neighboring gene solute carrier family 66 member 3 Neighboring gene chromosome 11 C2orf50 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). Amano M, et al. J Biol Chem, 1996 Aug 23. PMID 8702756
    2. Isolation and partial sequence of bovine cDNA clones for the high-mobility-group protein (HMG-1). Pentecost B, et al. Biosci Rep, 1984 Jan. PMID 6141822
    3. Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase. Shimizu T, et al. J Biol Chem, 2003 Nov 14. PMID 12954645
    4. RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability. Clements RT, et al. Am J Physiol Lung Cell Mol Physiol, 2005 Feb. PMID 15475381
    5. The Rho-associated protein kinase p160ROCK is required for centrosome positioning. Chevrier V, et al. J Cell Biol, 2002 May 27. PMID 12034773, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rho-kinase analysis of coiled-coil association of the RhoA-binding domain
      Title: Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase.
    2. nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity
      Title: Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase.
    3. RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.
      Title: RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho-associated protein kinase 2
    Names
    p164 ROCK-2
    rho-associated, coiled-coil-containing protein kinase 2
    rho-associated, coiled-coil-containing protein kinase II
    NP_776877.1
    XP_059747003.1
    XP_059747004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174452.2 → NP_776877.1  rho-associated protein kinase 2

      Status: PROVISIONAL

      Source sequence(s)
      U36909
      UniProtKB/Swiss-Prot
      Q28021
      UniProtKB/TrEMBL
      A0A3Q1LJY9
      Related
      ENSBTAP00070008407.1, ENSBTAT00070014566.1
      Conserved Domains (7) summary
      cd11638
      Location:505 → 571
      HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
      smart00220
      Location:92 → 354
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:437 → 1101
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1261 → 1307
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1151 → 1257
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05621
      Location:39 → 417
      STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2
      pfam08912
      Location:979 → 1046
      Rho_Binding; Rho Binding

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      86489043..86617614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891020.1 → XP_059747003.1  rho-associated protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MW77

    2. XM_059891021.1 → XP_059747004.1  rho-associated protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MW77
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28021.1 GenPept UniProtKB/Swiss-Prot:Q28021

    Gene LinkOut

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