S100A1 S100 calcium binding protein A1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: S100A1provided by VGNC
Official Full Name: S100 calcium binding protein A1provided by VGNC
Primary source: VGNC:VGNC:34236
See related: BGD:BT11116; Ensembl:ENSBTAG00000005163
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (16751807..16756164, complement)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified S100A1, but not calmodulin or other S100 proteins, as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex (S100A1)
Title: S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex.
Results suggest that S100A1 can act as a linker between the calcium and redox signalling pathways.
Title: Affinity of S100A1 protein for calcium increases dramatically upon glutathionylation.
beta-mercaptoethanol modification of apo-S100A1 makes its structure more similar to that of holo-S100A1, so that it becomes much better adjusted for calcium coordination.
Title: Structural and motional changes induced in apo-S100A1 protein by the disulfide formation between its Cys 85 residue and beta-mercaptoethanol.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables S100 protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of heart contraction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein S100-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099042.2 → NP_001092512.1 protein S100-A1

See identical proteins and their annotated locations for NP_001092512.1

Status: PROVISIONAL

Source sequence(s)

BC141991

UniProtKB/Swiss-Prot

A5PJ73, P02639

Related

ENSBTAP00000006806.4, ENSBTAT00000006806.6

Conserved Domains (1) summary

cd05025
Location:2 → 93

S-100A1; S-100A1 domain found in proteins similar to S100A1. S100A1 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

16751807..16756164 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005203720.4 → XP_005203777.1 protein S100-A1 isoform X1

See identical proteins and their annotated locations for XP_005203777.1

Conserved Domains (2) summary

pfam13499
Location:146 → 169

EF-hand_7; EF-hand domain pair

cl08302
Location:139 → 186

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_005203721.5 → XP_005203778.1 protein S100-A1 isoform X2

See identical proteins and their annotated locations for XP_005203778.1

UniProtKB/Swiss-Prot

A5PJ73, P02639

Conserved Domains (1) summary

cd05025
Location:2 → 93

S-100A1; S-100A1 domain found in proteins similar to S100A1. S100A1 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...