CAT catalase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CATprovided by VGNC
Official Full Name: catalaseprovided by VGNC
Primary source: VGNC:VGNC:26792
See related: Ensembl:ENSBTAG00000020980
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (64975290..65011234)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction of artemisinin protects the activity of antioxidant enzyme catalase: A biophysical study.
Title: Interaction of artemisinin protects the activity of antioxidant enzyme catalase: A biophysical study.
The interactions between cationic surfactants dodecyltrimethylammonium bromide (DTAB) and tetradecyltrimethylammonium bromide (TTAB) with varying alkyl chain lengths and bovine liver catalase (BLC) were examined by various biophysical approaches.
Title: Cationic surfactant mediated fibrillogenesis in bovine liver catalase: a biophysical approach.
Enzyme activity assay and molecular docking revealed that the activity of CAT was slightly inhibited in the presence of Sudan dyes. In comparison, the binding of Sudan II with CAT was slightly stronger than Sudan IV. Also, Sudan II and Sudan IV showed a different impact on the microenvironment of aromatic amino acid residues.
Title: Comparison of the toxicity of the dyes Sudan II and Sudan IV to catalase.
the decrease in accessible surface area and increase in pKa of important lysine residues were considered as predominant factors in decreased glycation of bovine liver catalase by curcumin.
Title: Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin.
ITC confirms the stability of bovine liver catalase (BLC)upon gemini combination. Docking provides support to fluorescence results by presenting the localization site of m-E2-m surfactants near to aromatic residues (mainly Tyr, Trp and Phe)
Title: Biophysical perspective of the binding of ester-functionalized gemini surfactants with catalase.
Data show that liver catalase is able to tolerate very high levels of the modifying alpha-oxoaldehyde methylglyoxal so that its essential enzymatic function is not impaired.
Title: Arg354 in the catalytic centre of bovine liver catalase is protected from methylglyoxal-mediated glycation.
The structure of bovine liver catalase determined from a single crystal at 3.2 A resolution by MicroED, is reported.
Title: Structure of catalase determined by MicroED.
These maps demonstrate that it is indeed possible to build atomic models from such crystals and even to determine the charged states of amino acid residues in the Ca(2+)-binding sites of Ca(2+)-ATPase and that of the iron atom in the heme in catalase.
Title: Electron crystallography of ultrathin 3D protein crystals: atomic model with charges.
Data indicate compatible osmolytes, proline, xylitol, and valine destabilize the denatured form of the catalase enzyme and, therefore, increase its disaggregation and thermal stability.
Title: Effect of compatible and noncompatible osmolytes on the enzymatic activity and thermal stability of bovine liver catalase.
Flavonoid inhibition of catalase activity is, at least partially, due to the formation of hydrogen bonds between catalase and the flavonoid.
Title: Catalase is inhibited by flavonoids.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BARC0014 (e-PCR)
- UniSTS:255302

MARC_24332-24333:1030112639:1 (e-PCR)
- UniSTS:268887

KP1 (e-PCR), detects polymorphism
- UniSTS:254142

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables catalase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: catalase

NP_001030463.1

EC 1.11.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.