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    Cttn cortactin [ Mus musculus (house mouse) ]

    Gene ID: 13043, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cttnprovided by MGI
    Official Full Name
    cortactinprovided by MGI
    Primary source
    MGI:MGI:99695
    See related
    Ensembl:ENSMUSG00000031078 AllianceGenome:MGI:99695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ems1; 1110020L01Rik
    Summary
    Predicted to enable several functions, including Arp2/3 complex binding activity; profilin binding activity; and proline-rich region binding activity. Involved in intracellular protein transport and regulation of mitophagy. Acts upstream of or within dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway; and substrate-dependent cell migration, cell extension. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Part of voltage-gated potassium channel complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and sensory organ. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 56.4), colon adult (RPKM 53.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cttn in Genome Data Viewer
    Location:
    7 F5; 7 88.84 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143989468..144024743, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144435724..144471560, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene predicted gene, 34621 Neighboring gene predicted gene, 34561 Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E6619 Neighboring gene STARR-positive B cell enhancer ABC_E9306 Neighboring gene predicted gene, 35626 Neighboring gene Fas associated via death domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables profilin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables profilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lamellipodium organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within substrate-dependent cell migration, cell extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    src substrate cortactin
    Names
    mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252572.2NP_001239501.1  src substrate cortactin isoform 2

      See identical proteins and their annotated locations for NP_001239501.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC140268
      Consensus CDS
      CCDS57599.1
      UniProtKB/TrEMBL
      Q8BNA5, Q921L6
      Related
      ENSMUSP00000033407.7, ENSMUST00000033407.13
      Conserved Domains (3) summary
      cd11959
      Location:455507
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:231266
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:299362
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    2. NM_001357116.2NP_001344045.1  src substrate cortactin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC140268
      UniProtKB/TrEMBL
      Q8BNA5
      Conserved Domains (4) summary
      cd11959
      Location:418470
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:157192
      HS1_rep; Repeat in HS1/Cortactin
      pfam15927
      Location:285326
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
      cl00489
      Location:272368
      60KD_IMP; 60Kd inner membrane protein
    3. NM_007803.6NP_031829.2  src substrate cortactin isoform 1

      See identical proteins and their annotated locations for NP_031829.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC140268
      Consensus CDS
      CCDS22049.1
      UniProtKB/Swiss-Prot
      Q3UGC2, Q60598
      UniProtKB/TrEMBL
      Q8BNA5
      Related
      ENSMUSP00000099368.4, ENSMUST00000103079.4
      Conserved Domains (3) summary
      cd11959
      Location:492544
      SH3_Cortactin; Src homology 3 domain of Cortactin
      pfam02218
      Location:157192
      HS1_rep; Repeat in HS1/Cortactin
      cl05005
      Location:336399
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143989468..144024743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001785469.3 RNA Sequence

    2. XR_003946381.2 RNA Sequence

    3. XR_003946382.2 RNA Sequence