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    Mkrn3 makorin, ring finger protein, 3 [ Mus musculus (house mouse) ]

    Gene ID: 22652, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mkrn3provided by MGI
    Official Full Name
    makorin, ring finger protein, 3provided by MGI
    Primary source
    MGI:MGI:2181178
    See related
    Ensembl:ENSMUSG00000070527 AllianceGenome:MGI:2181178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp127; D7H15S9-1
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in gut; nervous system; and sensory organ. Used to study central precocious puberty 2. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to human MKRN3 (makorin ring finger protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Mkrn3 in Genome Data Viewer
    Location:
    7 C; 7 34.37 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (62067341..62069901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (62417593..62420153, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32061 Neighboring gene necdin, MAGE family member Neighboring gene MAGE family member L2 Neighboring gene STARR-seq mESC enhancer starr_18999 Neighboring gene paternally expressed 12 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase makorin-3
    Names
    RING-type E3 ubiquitin transferase makorin-3
    zinc finger protein 127
    NP_035876.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011746.3NP_035876.2  probable E3 ubiquitin-protein ligase makorin-3

      See identical proteins and their annotated locations for NP_035876.2

      Status: VALIDATED

      Source sequence(s)
      AC156555
      Consensus CDS
      CCDS21327.1
      UniProtKB/Swiss-Prot
      Q3UY92, Q60764, Q7TQE4
      Related
      ENSMUSP00000091898.4, ENSMUST00000094340.4
      Conserved Domains (3) summary
      smart00356
      Location:92118
      ZnF_C3H1; zinc finger
      cd00162
      Location:347401
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam15815
      Location:467542
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      62067341..62069901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)