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    Foxa3 forkhead box A3 [ Mus musculus (house mouse) ]

    Gene ID: 15377, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxa3provided by MGI
    Official Full Name
    forkhead box A3provided by MGI
    Primary source
    MGI:MGI:1347477
    See related
    Ensembl:ENSMUSG00000040891 AllianceGenome:MGI:1347477
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnf3g; Tcf3g; Hnf-3g; Tcf-3g
    Summary
    Enables sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II and spermatogenesis. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; intracellular glucose homeostasis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and skeleton. Orthologous to human FOXA3 (forkhead box A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 32.1), colon adult (RPKM 31.9) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Foxa3 in Genome Data Viewer
    Location:
    7 A3; 7 9.46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18747208..18757464, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19013283..19023539, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Myb-related transcription factor, partner of profilin Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene symplekin Neighboring gene radial spoke head 6 homolog A (Chlamydomonas)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hepatocyte nuclear factor 3-gamma
    Names
    HNF-3-gamma
    forkhead box protein A3
    hepatocyte nuclear factor 3 gamma (winged helix transcription factor)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008260.2NP_032286.1  hepatocyte nuclear factor 3-gamma

      Status: PROVISIONAL

      Source sequence(s)
      AC170864
      Consensus CDS
      CCDS20886.1
      UniProtKB/Swiss-Prot
      P35584
      UniProtKB/TrEMBL
      Q8JZU4
      Related
      ENSMUSP00000043173.6, ENSMUST00000036018.6
      Conserved Domains (1) summary
      smart00339
      Location:119207
      FH; FORKHEAD

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18747208..18757464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)