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    Kat8 K(lysine) acetyltransferase 8 [ Mus musculus (house mouse) ]

    Gene ID: 67773, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kat8provided by MGI
    Official Full Name
    K(lysine) acetyltransferase 8provided by MGI
    Primary source
    MGI:MGI:1915023
    See related
    Ensembl:ENSMUSG00000030801 AllianceGenome:MGI:1915023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOF; mMof; Myst1; MYST-1; D7Ertd629e; 2010203C02Rik; 5830450F21Rik
    Summary
    Enables enzyme binding activity; histone H4K16 acetyltransferase activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of skeletal muscle satellite cell differentiation; post-embryonic hemopoiesis; and regulation of gene expression. Located in kinetochore and nuclear matrix. Part of MSL complex and NSL complex. Is active in chromosome; mitochondrion; and nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; limb; nervous system; and respiratory system. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.3), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kat8 in Genome Data Viewer
    Location:
    7 F3; 7 69.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127511689..127525010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127912517..127925838)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E11370 Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene STARR-seq mESC enhancer starr_20195 Neighboring gene serine protease 8 (prostasin) Neighboring gene STARR-positive B cell enhancer ABC_E6608 Neighboring gene serine protease 36 Neighboring gene predicted gene, 53375 Neighboring gene STARR-seq mESC enhancer starr_20197 Neighboring gene fused in sarcoma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K16 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H4K16 acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to histone H4K16 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K16 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone H4K16 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H4K16 propionyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone H4K5 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H4K5 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone H4K8 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H4K8 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-lysine-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein propionyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein propionyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in dosage compensation by inactivation of X chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of skeletal muscle satellite cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in post-embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MSL complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MSL complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT8
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
    MYST histone acetyltransferase 1
    histone acetyltransferase Myst1
    lysine acetyltransferase 8
    males-absent on the first protein homolog
    probable histone acetyltransferase MYST1
    protein acetyltransferase KAT8
    protein propionyltransferase KAT8
    NP_001347628.1
    NP_080646.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360699.1NP_001347628.1  histone acetyltransferase KAT8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC149222
      Conserved Domains (1) summary
      PLN00104
      Location:6291
      PLN00104; MYST -like histone acetyltransferase; Provisional
    2. NM_026370.2NP_080646.1  histone acetyltransferase KAT8 isoform 1

      See identical proteins and their annotated locations for NP_080646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132000, AK146710
      Consensus CDS
      CCDS21885.1
      UniProtKB/Swiss-Prot
      Q3UIY0, Q8BJ69, Q8BJ76, Q8CI73, Q9D1P2
      UniProtKB/TrEMBL
      Q3V268
      Related
      ENSMUSP00000033070.8, ENSMUST00000033070.9
      Conserved Domains (1) summary
      PLN00104
      Location:21449
      PLN00104; MYST -like histone acetyltransferase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127511689..127525010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)