U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Stard13 StAR related lipid transfer domain containing 13 [ Mus musculus (house mouse) ]

    Gene ID: 243362, updated on 27-Nov-2024

    Summary

    Official Symbol
    Stard13provided by MGI
    Official Full Name
    StAR related lipid transfer domain containing 13provided by MGI
    Primary source
    MGI:MGI:2385331
    See related
    Ensembl:ENSMUSG00000016128 AllianceGenome:MGI:2385331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLC2; GT650
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of sprouting angiogenesis. Predicted to be located in lipid droplet and mitochondrial membrane. Orthologous to human STARD13 (StAR related lipid transfer domain containing 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 12.8), bladder adult (RPKM 6.2) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stard13 in Genome Data Viewer
    Location:
    5 G3; 5 89.82 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150960975..151351780, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (151037515..151428200, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene klotho Neighboring gene predicted gene 8675 Neighboring gene STARR-seq mESC enhancer starr_14970 Neighboring gene STARR-seq mESC enhancer starr_14971 Neighboring gene RIKEN cDNA 5430435K18 gene Neighboring gene predicted gene, 52834 Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene RIKEN cDNA 1700028E10 gene Neighboring gene STARR-seq mESC enhancer starr_14974 Neighboring gene STARR-seq mESC enhancer starr_14976 Neighboring gene vomeronasal 2, receptor, pseudogene 25 Neighboring gene predicted gene 3704 Neighboring gene vomeronasal 2, receptor, pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC38133

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    stAR-related lipid transfer protein 13
    Names
    START domain-containing protein 13
    StAR-related lipid transfer (START) domain containing 13
    serologically defined colon cancer antigen 13
    serologically defined colon cancer antigen 28

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163493.2NP_001156965.1  stAR-related lipid transfer protein 13 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC109614, AC163219
      Consensus CDS
      CCDS51710.1
      UniProtKB/TrEMBL
      A0A2X0SFI9, F8WIY7
      Related
      ENSMUSP00000053232.9, ENSMUST00000062015.15
      Conserved Domains (4) summary
      cd09592
      Location:57120
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:61120
      SAM; Sterile alpha motif
      cd04375
      Location:676893
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
      cl14643
      Location:9201123
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    2. NM_001359985.2NP_001346914.1  stAR-related lipid transfer protein 13 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC109614, AC163219
      UniProtKB/TrEMBL
      A0A2X0SFI9
      Conserved Domains (2) summary
      cd04375
      Location:481698
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:725928
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    3. NM_001424723.1NP_001411652.1  stAR-related lipid transfer protein 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109614, AC163219
    4. NM_001424724.1NP_001411653.1  stAR-related lipid transfer protein 13 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109614, AC163219
    5. NM_001424725.1NP_001411654.1  stAR-related lipid transfer protein 13 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109614, AC163219
      UniProtKB/TrEMBL
      A0A0J9YU82
      Related
      ENSMUSP00000144056.2, ENSMUST00000202111.4
    6. NM_001424726.1NP_001411655.1  stAR-related lipid transfer protein 13 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109614, AC163219
      UniProtKB/TrEMBL
      A0A0J9YU82
    7. NM_001424727.1NP_001411656.1  stAR-related lipid transfer protein 13 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109614, AC163219
    8. NM_001424728.1NP_001411657.1  stAR-related lipid transfer protein 13 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109614, AC163219
    9. NM_146258.3NP_666370.3  stAR-related lipid transfer protein 13 isoform 2

      See identical proteins and their annotated locations for NP_666370.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a protein (isoform 2) that is 19 amino acids shorter than isoform 1.
      Source sequence(s)
      AC109614, AC163219
      Consensus CDS
      CCDS19890.1
      UniProtKB/Swiss-Prot
      E9PUB5, Q8K369, Q923Q2
      UniProtKB/TrEMBL
      A0A2X0SFI9
      Related
      ENSMUSP00000106109.3, ENSMUST00000110483.9
      Conserved Domains (4) summary
      cd09592
      Location:57120
      SAM_DLC2; SAM domain of STARD13-like subfamily
      smart00454
      Location:61120
      SAM; Sterile alpha motif
      cd04375
      Location:657874
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
      cl14643
      Location:9011104
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RNA

    1. NR_153382.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC109614, AC163219

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      150960975..151351780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504923.5XP_006504986.1  stAR-related lipid transfer protein 13 isoform X3

      See identical proteins and their annotated locations for XP_006504986.1

      UniProtKB/TrEMBL
      A0A2X0SFI9
      Conserved Domains (2) summary
      cd04375
      Location:558775
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:8021005
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    2. XM_006504918.5XP_006504981.1  stAR-related lipid transfer protein 13 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFI9
      Conserved Domains (3) summary
      cd09592
      Location:42105
      SAM_DLC2; SAM domain of STARD13-like subfamily
      cd04375
      Location:661878
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:9051108
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    3. XM_006504921.3XP_006504984.1  stAR-related lipid transfer protein 13 isoform X3

      See identical proteins and their annotated locations for XP_006504984.1

      UniProtKB/TrEMBL
      A0A2X0SFI9
      Conserved Domains (2) summary
      cd04375
      Location:558775
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:8021005
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    4. XM_036165136.1XP_036021029.1  stAR-related lipid transfer protein 13 isoform X5

      UniProtKB/TrEMBL
      A0A0J9YU82, A0A2X0SFI9
      Conserved Domains (2) summary
      cd04375
      Location:539756
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:783986
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    5. XM_006504922.5XP_006504985.1  stAR-related lipid transfer protein 13 isoform X3

      See identical proteins and their annotated locations for XP_006504985.1

      UniProtKB/TrEMBL
      A0A2X0SFI9
      Conserved Domains (2) summary
      cd04375
      Location:558775
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:8021005
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    6. XM_036165133.1XP_036021026.1  stAR-related lipid transfer protein 13 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFI9
      Conserved Domains (2) summary
      cd04375
      Location:550767
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
      cl14643
      Location:794997
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RNA

    1. XR_004942515.1 RNA Sequence