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    Thbs3 thrombospondin 3 [ Mus musculus (house mouse) ]

    Gene ID: 21827, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thbs3provided by MGI
    Official Full Name
    thrombospondin 3provided by MGI
    Primary source
    MGI:MGI:98739
    See related
    Ensembl:ENSMUSG00000028047 AllianceGenome:MGI:98739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSP3; Thbs-3
    Summary
    Predicted to enable heparin binding activity. Acts upstream of or within bone trabecula formation; growth plate cartilage development; and ossification involved in bone maturation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including brain; lung; musculoskeletal system; sensory organ; and urinary system. Orthologous to human THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 35.8), lung adult (RPKM 25.6) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Thbs3 in Genome Data Viewer
    Location:
    3 F1; 3 39.01 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89122470..89134148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89215180..89226841)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene metaxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E11197 Neighboring gene STARR-seq mESC enhancer starr_08226 Neighboring gene predicted gene, 57704 Neighboring gene STARR-positive B cell enhancer ABC_E11198 Neighboring gene microRNA 92b Neighboring gene mucin 1, transmembrane

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013691.3NP_038719.2  thrombospondin-3 precursor

      See identical proteins and their annotated locations for NP_038719.2

      Status: VALIDATED

      Source sequence(s)
      AC161600, BC053023, BP754474, CJ064850
      Consensus CDS
      CCDS17495.1
      UniProtKB/Swiss-Prot
      Q05895, Q6LCE0, Q7TN15
      UniProtKB/TrEMBL
      E9PWF0
      Related
      ENSMUSP00000029682.5, ENSMUST00000029682.11
      Conserved Domains (9) summary
      cd00054
      Location:316352
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:528550
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:551586
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:457491
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:552586
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:741938
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:378407
      EGF_3; EGF domain
      cd16079
      Location:227269
      TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
      cl22861
      Location:21193
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RNA

    1. NR_149740.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132327, AC161600, BP754474
      Related
      ENSMUST00000126315.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89122470..89134148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501295.3XP_006501358.1  thrombospondin-3 isoform X1

      Conserved Domains (8) summary
      cd00054
      Location:111147
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:323345
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:346381
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:252286
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:346381
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:536733
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:173202
      EGF_3; EGF domain
      NF000535
      Location:257447
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC