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    Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 [ Mus musculus (house mouse) ]

    Gene ID: 11438, updated on 3-Dec-2024

    Summary

    Official Symbol
    Chrna4provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, alpha polypeptide 4provided by MGI
    Primary source
    MGI:MGI:87888
    See related
    Ensembl:ENSMUSG00000027577 AllianceGenome:MGI:87888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EBN1; Acra4; ENFL1; Acra-4
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Contributes to acetylcholine receptor activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic signaling. Located in external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 15.0), whole brain E14.5 (RPKM 7.5) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Chrna4 in Genome Data Viewer
    Location:
    2 H4; 2 103.54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180664104..180685339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181022311..181043579, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ARF GTPase activating protein 1 Neighboring gene collagen, type XX, alpha 1 Neighboring gene potassium voltage-gated channel, subfamily Q, member 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables quaternary ammonium group binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inhibitory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within membrane depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nicotine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to nicotine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of pain TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within synaptic transmission, cholinergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of acetylcholine-gated channel complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in presynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit alpha-4
    Names
    a4 nicotinic receptor
    acetylcholine receptor alpha 4 neural
    acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit
    alpha4 nAChR

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416868.1NP_001403797.1  neuronal acetylcholine receptor subunit alpha-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL450341
      UniProtKB/TrEMBL
      B7ZBU7
    2. NM_015730.6NP_056545.3  neuronal acetylcholine receptor subunit alpha-4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_056545.3

      Status: VALIDATED

      Source sequence(s)
      AL450341
      Consensus CDS
      CCDS17192.1
      UniProtKB/Swiss-Prot
      O70174, Q8BHE9, Q8VI10, Q9ET51
      UniProtKB/TrEMBL
      B7ZBU7, Q53YK0
      Related
      ENSMUSP00000066338.8, ENSMUST00000067120.14
      Conserved Domains (2) summary
      pfam02931
      Location:39245
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:252620
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180664104..180685339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246772.2XP_030102632.1  neuronal acetylcholine receptor subunit alpha-4 isoform X2

      Conserved Domains (3) summary
      cl28912
      Location:166
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
      pfam02932
      Location:74441
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
      pfam05350
      Location:257344
      GSK-3_bind; Glycogen synthase kinase-3 binding