Hsd17b8 hydroxysteroid 17-beta dehydrogenase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsd17b8provided by MGI
Official Full Name: hydroxysteroid 17-beta dehydrogenase 8provided by MGI
Primary source: MGI:MGI:95911
See related: Ensembl:ENSMUSG00000073422 AllianceGenome:MGI:95911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ke6; Ke-6; Ring2; H-2Ke6; H2-Ke6; D17H6S112E
Summary: Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Acts upstream of or within androgen metabolic process and estrogen metabolic process. Located in mitochondrial envelope and plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 155.4), ovary adult (RPKM 72.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34245007..34247029, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34026033..34028055, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI117660 (e-PCR)
- UniSTS:181002

M32010 (e-PCR)
- UniSTS:181010

H2-Ke6 (e-PCR), detects polymorphism
- UniSTS:463413

Slc39a7 (e-PCR), detects polymorphism
- UniSTS:463430

RH124680 (e-PCR)
- UniSTS:161502

RH125458 (e-PCR)
- UniSTS:162277

MARC_5283-5284:991939549:1 (e-PCR)
- UniSTS:231147

MARC_5283-5284:996690262:1 (e-PCR)
- UniSTS:231147

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables NADH binding	ISO Inferred from Sequence Orthology more info
enables NADH binding	ISS Inferred from Sequence or Structural Similarity more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISS Inferred from Sequence or Structural Similarity more info
enables quinone binding	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within androgen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within estrogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial envelope	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
part_of oxidoreductase complex	IEA Inferred from Electronic Annotation more info
part_of oxidoreductase complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: (3R)-3-hydroxyacyl-CoA dehydrogenase

Names: 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; H2-K region expressed gene 6; KAR alpha subunit; estradiol 17-beta-dehydrogenase 8; estrogen 17-oxidoreductase; testosterone 17-beta-dehydrogenase 8

NP_038571.2

EC 1.1.1.239

EC 1.1.1.62

EC 1.1.1.n12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013543.2 → NP_038571.2 (3R)-3-hydroxyacyl-CoA dehydrogenase

See identical proteins and their annotated locations for NP_038571.2

Status: VALIDATED

Source sequence(s)

BC086927, CX243612

Consensus CDS

CCDS50071.1

UniProtKB/Swiss-Prot

P50171, Q5M9K0, Q60958, Q60959, Q9Z1W2

UniProtKB/TrEMBL

A0A068BEQ2

Related

ENSMUSP00000038069.8, ENSMUST00000045467.14

Conserved Domains (2) summary

PRK05653
Location:12 → 259

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

cl21454
Location:11 → 258

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins