U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Espnl espin-like [ Mus musculus (house mouse) ]

    Gene ID: 227357, updated on 9-Dec-2024

    Summary

    Official Symbol
    Espnlprovided by MGI
    Official Full Name
    espin-likeprovided by MGI
    Primary source
    MGI:MGI:2685402
    See related
    Ensembl:ENSMUSG00000049515 AllianceGenome:MGI:2685402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm556
    Summary
    Enables actin filament binding activity. Involved in sensory perception of sound. Is active in stereocilium tip. Is expressed in metanephros; saccule; submandibular gland; and testis. Orthologous to human ESPNL (espin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Espnl in Genome Data Viewer
    Location:
    1 D; 1 46.08 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91249845..91277130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91322075..91348303)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E794 Neighboring gene zinc finger protein 330 pseudogene Neighboring gene selenocysteine lyase Neighboring gene kelch-like 30 Neighboring gene erythroferrone Neighboring gene integrin-linked kinase-associated serine/threonine phosphatase 2C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in stereocilium tip EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in stereocilium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033292.4NP_001028464.1  espin-like protein

      See identical proteins and their annotated locations for NP_001028464.1

      Status: VALIDATED

      Source sequence(s)
      AC110510
      Consensus CDS
      CCDS15160.1
      UniProtKB/Swiss-Prot
      Q3UYR4
      UniProtKB/TrEMBL
      H3BLK9
      Related
      ENSMUSP00000086294.4, ENSMUST00000088904.10
      Conserved Domains (4) summary
      cd00204
      Location:204323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:209301
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:72124
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:204236
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91249845..91277130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)