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    ZNF584 zinc finger protein 584 [ Homo sapiens (human) ]

    Gene ID: 201514, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF584provided by HGNC
    Official Full Name
    zinc finger protein 584provided by HGNC
    Primary source
    HGNC:HGNC:27318
    See related
    Ensembl:ENSG00000171574 AllianceGenome:HGNC:27318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 2.4), skin (RPKM 2.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF584 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58401558..58418327)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61497666..61514284)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58920016..58929694)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15195 Neighboring gene long intergenic non-protein coding RNA 2560 Neighboring gene ZNF584 divergent transcript Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58919203-58919848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11082 Neighboring gene zinc finger protein 324B Neighboring gene zinc finger protein 132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58951186-58951696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58952208-58952717 Neighboring gene ZNF132 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Methylomics of breast cancer: Seeking epimarkers in peripheral blood of young subjects. Khakpour G, et al. Tumour Biol, 2017 Mar. PMID 28349825
    2. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
    3. Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis. Li H, et al. Cell Rep, 2022 Dec 20. PMID 36543142
    4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39899

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 584

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318002.2 → NP_001304931.1  zinc finger protein 584 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and contains an alternate exon the in the 3' coding region that results in a frameshift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC012313, AK290068, AK298929, BC033149, DB053426, DC350090
      Consensus CDS
      CCDS82414.1
      UniProtKB/TrEMBL
      B4DQS1, F6W0P0
      Related
      ENSP00000320731.7, ENST00000322834.7
      Conserved Domains (2) summary
      smart00349
      Location:9 → 69
      KRAB; krueppel associated box
      pfam01352
      Location:9 → 48
      KRAB; KRAB box

    2. NM_001363680.1 → NP_001350609.1  zinc finger protein 584 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK290068, BC033149, BX333264, DB062261
      Consensus CDS
      CCDS86814.1
      UniProtKB/TrEMBL
      M0R0A3
      Related
      ENSP00000471105.1, ENST00000593920.5
      Conserved Domains (2) summary
      COG5048
      Location:144 → 329
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_173548.3 → NP_775819.1  zinc finger protein 584 isoform 1

      See identical proteins and their annotated locations for NP_775819.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC012313, AK290068, BC033149, DC350090
      Consensus CDS
      CCDS12979.1
      UniProtKB/Swiss-Prot
      A8K203, Q8IVC4
      Related
      ENSP00000306756.3, ENST00000306910.9
      Conserved Domains (6) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      COG5048
      Location:189 → 374
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:216 → 236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:214 → 236
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:17 → 56
      KRAB; KRAB box
      pfam13465
      Location:229 → 253
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_134461.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC012313, AK290068, BC017651, BC033149, BM828452, DC350090
      Related
      ENST00000599238.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58401558..58418327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438392.1 → XP_047294348.1  zinc finger protein 584 isoform X3

    2. XM_047438391.1 → XP_047294347.1  zinc finger protein 584 isoform X1

    3. XM_005258630.6 → XP_005258687.1  zinc finger protein 584 isoform X4

      UniProtKB/TrEMBL
      B4DQS1
      Conserved Domains (2) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      pfam01352
      Location:17 → 56
      KRAB; KRAB box

    4. XM_005258628.6 → XP_005258685.1  zinc finger protein 584 isoform X2

      Conserved Domains (6) summary
      smart00349
      Location:9 → 69
      KRAB; krueppel associated box
      COG5048
      Location:181 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:208 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:206 → 228
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:9 → 48
      KRAB; KRAB box
      pfam13465
      Location:221 → 245
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61497666..61514284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320178.1 → XP_054176153.1  zinc finger protein 584 isoform X6

    2. XM_054320176.1 → XP_054176151.1  zinc finger protein 584 isoform X5

    3. XM_054320179.1 → XP_054176154.1  zinc finger protein 584 isoform X4

    4. XM_054320177.1 → XP_054176152.1  zinc finger protein 584 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IVC4.1 GenPept UniProtKB/Swiss-Prot:Q8IVC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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