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    CSN4 COP9 signalosome subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35759, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CSN4provided by FlyBase
    Official Full Name
    COP9 signalosome subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0027054
    Locus tag
    Dmel_CG8725
    See related
    AllianceGenome:FB:FBgn0027054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8725; CH4; Cops4; csn4; Csn4; Dch4; DCH4; Dmel\CG8725; l(2)k08018
    Summary
    Enables transcription cis-regulatory region binding activity. Involved in several processes, including female germ-line stem cell population maintenance; male germ-line cyst encapsulation; and protein deneddylation. Part of COP9 signalosome. Is expressed in adult head and organism. Orthologous to human COPS4 (COP9 signalosome subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CSN4 in Genome Data Viewer
    Location:
    43F9-44A1; 2-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7972175..7974099)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3859680..3861604)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene spenito Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Acetyl-CoA carboxylase Neighboring gene Nucleoporin at 44A Neighboring gene long non-coding RNA:CR44272

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eukaryotic development. Schwechheimer C. Biochim Biophys Acta, 2004 Nov 29. PMID 15571808
    2. The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. Knowles A, et al. J Neurosci, 2009 Jan 28. PMID 19176824, Free PMC Article
    3. TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals. Betsch L, et al. PLoS Genet, 2019 Jan. PMID 30695029, Free PMC Article
    4. The COP9 signalosome: more than a protease. Wei N, et al. Trends Biochem Sci, 2008 Dec. PMID 18926707
    5. Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression. Oron E, et al. Mol Syst Biol, 2007. PMID 17486136, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP
      Title: TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
    2. COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
      Title: COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
    3. the CSN4 subunit of the COP9 signalosome co-occupies retinoblastoma target gene promoters with Rbf2
      Title: Retinoblastoma protein regulation by the COP9 signalosome.
    4. we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway
      Title: The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COP9 signalosome subunit 4
    Names
    CG8725-PA
    CG8725-PB
    COP9 complex homolog subunit 4
    CSN4-PA
    CSN4-PB
    drosophila COP9 signalosome homolog 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7972175..7974099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058096.4 → NP_477444.1  COP9 signalosome subunit 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477444.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V345, Q9XYW5
      UniProtKB/TrEMBL
      E1JH01
      Related
      FBpp0087935
      Conserved Domains (2) summary
      COG5071
      Location:95 → 384
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:271 → 369
      PCI; PCI domain

    2. NM_001169609.2 → NP_001163080.1  COP9 signalosome subunit 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V345, Q9XYW5
      UniProtKB/TrEMBL
      E1JH01
      Conserved Domains (2) summary
      COG5071
      Location:95 → 384
      RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:271 → 369
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JH01 E1JH01
    Q9V345.1 Q9V345

    Gene LinkOut

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