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    Cpn Calphotin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpnprovided by FlyBase
    Official Full Name
    Calphotinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261714
    Locus tag
    Dmel_CG4795
    See related
    AllianceGenome:FB:FBgn0261714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    77H5; Ag 72H5; Ag72H5; cap; CG4795; cpn; Dmel\CG4795; Mab77H5
    Summary
    Enables calcium ion binding activity. Involved in rhabdomere development and sequestering of calcium ion. Located in axon; cell body; and cytoplasm. Is expressed in adult optic lobe; eye photoreceptor cell; eye-antennal disc; head; and ocellus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpn in Genome Data Viewer
    Location:
    87B1-87B1; 3-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12162887..12166186, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7988609..7991908, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Lysine-TTT 2-5 Neighboring gene defective proboscis extension response 15 Neighboring gene eukaryotic translation initiation factor 3 subunit d2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calphotin: a Drosophila photoreceptor cell calcium-binding protein. Martin JH, et al. Proc Natl Acad Sci U S A, 1993 Feb 15. PMID 8094559, Free PMC Article
    2. A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells. Weiss S, et al. Channels (Austin), 2015. PMID 25664921, Free PMC Article
    3. Targeted gene mutations in Drosophila. Ballinger DG, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2556711, Free PMC Article
    4. A Drosophila photoreceptor cell-specific protein, calphotin, binds calcium and contains a leucine zipper. Ballinger DG, et al. Proc Natl Acad Sci U S A, 1993 Feb 15. PMID 8434015, Free PMC Article
    5. Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration. Weiss S, et al. J Neurosci, 2012 Oct 17. PMID 23077055, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of calcium ion IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in sequestering of calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sequestering of calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calphotin
    Names
    CG4795-PA
    CG4795-PB
    Cpn-PA
    Cpn-PB
    calcium-binding protein
    monoclonal antibody 77H5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12162887..12166186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169454.2 → NP_731673.1  calphotin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02910
      Related
      FBpp0082020
      Conserved Domains (1) summary
      pfam07462
      Location:101 → 159
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus

    2. NM_169455.2 → NP_731674.1  calphotin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731674.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X510, Q02910, Q95U45, Q9VGC8, Q9VGC9
      Related
      FBpp0082021
      Conserved Domains (1) summary
      PRK10811
      Location:228 → 409
      rne; ribonuclease E; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02910.2 Q02910

    Gene LinkOut

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