PTPMT1 Protein tyrosine phosphatase, mitochondrial 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PTPMT1provided by FlyBase
Official Full Name: Protein tyrosine phosphatase, mitochondrial 1provided by FlyBase
Primary source: FLYBASE:FBgn0039111
Locus tag: Dmel_CG10371
See related: AllianceGenome:FB:FBgn0039111
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 150466_at; CG10371; Dmel\CG10371; dPTEN; dPTPMT1; plip; Plip; PLIP
Summary: Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in cardiolipin biosynthetic process. Is active in mitochondrion. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and gut section. Orthologous to human PTPMT1 (protein tyrosine phosphatase mitochondrial 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 95B1-95B1; 3-80 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23758339..23759606)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19584061..19585328)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatidylglycerophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein tyrosine phosphatase, mitochondrial 1

Names: CG10371-PA; CG10371-PB; MKP-like; PTEN-like phosphatase; PTPMT1-PA; PTPMT1-PB

NP_651180.3

EC 3.1.3.-

EC 3.1.3.27

EC 3.1.3.36

NP_732901.1

EC 3.1.3.-

EC 3.1.3.27

EC 3.1.3.36

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23758339..23759606

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142923.3 → NP_651180.3 protein tyrosine phosphatase, mitochondrial 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651180.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86BN8, Q8SZ90, Q9VCI6

UniProtKB/TrEMBL

B5RJ36

Related

FBpp0083844

Conserved Domains (1) summary

cd14524
Location:31 → 194

PTPMT1; protein-tyrosine phosphatase mitochondrial 1
NM_170090.2 → NP_732901.1 protein tyrosine phosphatase, mitochondrial 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732901.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86BN8

Related

FBpp0083845

Conserved Domains (1) summary

cl21483
Location:55 → 186

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...