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    Gyg Glycogenin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gygprovided by FlyBase
    Official Full Name
    Glycogeninprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265191
    Locus tag
    Dmel_CG44244
    See related
    AllianceGenome:FB:FBgn0265191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG44244; CG9480; Dmel\CG44244; NEST:bs16a02
    Old locus tag
    Dmel_CG9480
    Summary
    Predicted to enable glycogenin glucosyltransferase activity. Predicted to be involved in glycogen biosynthetic process. Located in cytosol. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle primordium; larval muscle cell; and larval muscle system. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to human GYG1 (glycogenin 1) and GYG2 (glycogenin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gyg in Genome Data Viewer
    Location:
    57D1-57D1; 2-94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21200483..21210821)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17087988..17098326)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tudor Neighboring gene Leucine-rich repeat activity-regulated protein at synapses Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 49 member B1 Neighboring gene UDP-glycosyltransferase family 49 member C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila embryos spatially sort their nutrient stores to facilitate their utilization. Kilwein MD, et al. Development, 2023 Oct 15. PMID 36805634, Free PMC Article
    2. Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster. Zhang HB, et al. PLoS Pathog, 2021 Aug. PMID 34383852, Free PMC Article
    3. Disrupted Glutamate Signaling in Drosophila Generates Locomotor Rhythms in Constant Light. de Azevedo RVM, et al. Front Physiol, 2020. PMID 32210832, Free PMC Article
    4. Sedentary Behavior Impacts on the Epigenome and Transcriptome: Lessons from Muscle Inactivation in Drosophila Larvae. Brener A, et al. Cells, 2023 Sep 22. PMID 37830547, Free PMC Article
    5. Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding. Silicheva M, et al. Nucleic Acids Res, 2010 Jan. PMID 19854952, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycogenin glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    glycogenin
    Names
    CG44244-PB
    CG44244-PD
    CG44244-PE
    CG44244-PG
    CG44244-PH
    CG44244-PI
    Gyg-PB
    Gyg-PD
    Gyg-PE
    Gyg-PG
    Gyg-PH
    Gyg-PI
    NP_001163232.2
    NP_001246446.1
    NP_001286666.1
    NP_001286667.1
    NP_001286668.1
    NP_726040.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21200483..21210821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299737.1 → NP_001286666.1  glycogenin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFW5
      Conserved Domains (2) summary
      cd02537
      Location:4 → 253
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      COG1442
      Location:94 → 251
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    2. NM_001299739.1 → NP_001286668.1  glycogenin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG72
      Conserved Domains (2) summary
      cd02537
      Location:4 → 253
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      COG1442
      Location:94 → 251
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    3. NM_001299738.1 → NP_001286667.1  glycogenin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG29
      Conserved Domains (2) summary
      cd02537
      Location:4 → 253
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      COG1442
      Location:94 → 251
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    4. NM_001259517.2 → NP_001246446.1  glycogenin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7X5
      Conserved Domains (2) summary
      cd02537
      Location:4 → 253
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      COG1442
      Location:94 → 251
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    5. NM_166432.3 → NP_726040.1  glycogenin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726040.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2J6
      Related
      FBpp0308233
      Conserved Domains (2) summary
      cd02537
      Location:4 → 253
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      COG1442
      Location:94 → 251
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    6. NM_001169761.4 → NP_001163232.2  glycogenin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163232.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGQ3
      Conserved Domains (2) summary
      cd02537
      Location:1 → 207
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      COG1442
      Location:48 → 205
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7X5 A0A0B4K7X5
    A0A0B4LFW5 A0A0B4LFW5
    A0A0B4LG29 A0A0B4LG29
    A0A0B4LG72 A0A0B4LG72
    E1JGQ3 E1JGQ3
    Q9W2J6 Q9W2J6

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