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    Twdlbeta Tweedlebeta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36265, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Twdlbetaprovided by FlyBase
    Official Full Name
    Tweedlebetaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033658
    Locus tag
    Dmel_CG8986
    See related
    AllianceGenome:FB:FBgn0033658
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8986; CT25838; Dmel\CG8986; TwdlBeta
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Twdlbeta in Genome Data Viewer
    Location:
    48C5-48C5; 2-65 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11862537..11863252, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7750042..7750757, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Megator Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Death associated molecule related to Mch2 caspase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. Guan X, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075064, Free PMC Article
    2. A Novel Neuron-Specific Regulator of the V-ATPase in Drosophila. Dulac A, et al. eNeuro, 2021 Sep-Oct. PMID 34620624, Free PMC Article
    3. pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos. Stathopoulos A, et al. Genes Dev, 2004 Mar 15. PMID 15075295, Free PMC Article
    4. How do Wolbachia modify the Drosophila ovary? New evidences support the "titration-restitution" model for the mechanisms of Wolbachia-induced CI. He Z, et al. BMC Genomics, 2019 Jul 24. PMID 31340757, Free PMC Article
    5. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tweedlebeta
    Names
    CG8986-PA
    TwdlBeta
    Twdlbeta-PA
    tweedle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11862537..11863252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136863.4 → NP_610707.2  tweedlebeta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610707.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8Q0, Q8SZ76
      Related
      FBpp0087168
      Conserved Domains (1) summary
      smart00690
      Location:68 → 167
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8Q0 A1Z8Q0
    Q8SZ76 Q8SZ76

    Gene LinkOut

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