Ance-3 Ance-3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ance-3provided by FlyBase
Official Full Name: Ance-3provided by FlyBase
Primary source: FLYBASE:FBgn0032536
Locus tag: Dmel_CG17988
See related: AllianceGenome:FB:FBgn0032536
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ance-3; BG:DS00180.5; CG17988; CG31766; CG31843; CT40163; Dmel\CG17988; DS00180.5
Summary: Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13914725..13956188)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13914725..13956188)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

An angiotensin converting enzyme homolog is required for volatile pheromone detection, odorant binding protein secretion and normal courtship behavior in Drosophila melanogaster.
Title: An angiotensin converting enzyme homolog is required for volatile pheromone detection, odorant binding protein secretion and normal courtship behavior in Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables metallopeptidase activity	IKR Inferred from Key Residues more info	PubMed
NOT enables peptidase activity	IKR Inferred from Key Residues more info	PubMed
NOT enables peptidyl-dipeptidase activity	IKR Inferred from Key Residues more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in proteolysis	IKR Inferred from Key Residues more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain