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    nonA no on or off transient A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nonAprovided by FlyBase
    Official Full Name
    no on or off transient Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004227
    Locus tag
    Dmel_CG4211
    See related
    AllianceGenome:FB:FBgn0004227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bj6; Bj6-1; CG4211; diss; Dmel\CG4211; dNONO; non-A; nona; NonA; NONA; nonA/diss; opm2; p54[nrb]; x14
    Summary
    Predicted to enable mRNA binding activity. Involved in male courtship behavior, veined wing generated song production and visual perception. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including Y chromosome loop; ganglia; germline cell; head; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding); PSPC1 (paraspeckle component 1); and SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nonA in Genome Data Viewer
    Location:
    14B18-14C1; 1-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16361569..16371547)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16255602..16265580)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene U2 small nuclear riboprotein auxiliary factor 50 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Q Neighboring gene Furin 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo observation of the puff-specific protein no-on transient A (NONA) in nuclei of Drosophila embryos. Buchenau P, et al. J Cell Sci, 1993 Sep. PMID 8270623
    2. The Hrp65 self-interaction is mediated by an evolutionarily conserved domain and is required for nuclear import of Hrp65 isoforms that lack a nuclear localization signal. Kiesler E, et al. J Cell Sci, 2003 Oct 1. PMID 12928329
    3. Artificial neural network classification of Drosophila courtship song mutants. Neumann EK, et al. Biol Cybern, 1992. PMID 1586673
    4. NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Yang YS, et al. Mol Cell Biol, 1993 Sep. PMID 8355702, Free PMC Article
    5. Temporally manipulated rescue of visual and courtship abnormalities caused by a nonA mutation in Drosophila. Rendahl KG, et al. J Neurogenet, 1996 Sep. PMID 8923298

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phototaxis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    no on or off transient A
    Names
    Bj6-monoclonal-antibody
    CG4211-PA
    CG4211-PB
    CG4211-PC
    CG4211-PD
    dissonance
    no on or off transient-A
    no-on transient A
    no-on-transient A
    no-on-transient-A
    non-on-transient-A
    nonA-PA
    nonA-PB
    nonA-PC
    nonA-PD
    positive spike II group

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16361569..16371547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167505.2 → NP_727962.1  no on or off transient A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7XBJ7, Q8IR16
      Related
      FBpp0074012
      Conserved Domains (5) summary
      cd12945
      Location:447 → 546
      NOPS_NONA_like; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSP1 homologs from invertebrate species
      cd12332
      Location:301 → 371
      RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
      cd12333
      Location:377 → 456
      RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
      cd16269
      Location:584 → 595
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:508 → 613
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001298395.1 → NP_001285324.1  no on or off transient A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04047, Q24261, Q59E42, Q9VXH1
      UniProtKB/TrEMBL
      L7XBJ7, X2JFR1
      Conserved Domains (5) summary
      cd12945
      Location:447 → 546
      NOPS_NONA_like; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSP1 homologs from invertebrate species
      cd12332
      Location:301 → 371
      RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
      cd12333
      Location:377 → 456
      RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
      cd16269
      Location:584 → 595
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:508 → 613
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001014747.2 → NP_001014747.1  no on or off transient A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7XBJ7
      Conserved Domains (5) summary
      cd12945
      Location:447 → 546
      NOPS_NONA_like; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSP1 homologs from invertebrate species
      cd12332
      Location:301 → 371
      RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
      cd12333
      Location:377 → 456
      RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
      cd16269
      Location:584 → 595
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:508 → 613
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. NM_078643.3 → NP_523367.2  no on or off transient A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523367.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04047, Q24261, Q59E42, Q9VXH1
      UniProtKB/TrEMBL
      L7XBJ7, X2JFR1
      Related
      FBpp0074011
      Conserved Domains (5) summary
      cd12945
      Location:447 → 546
      NOPS_NONA_like; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSP1 homologs from invertebrate species
      cd12332
      Location:301 → 371
      RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
      cd12333
      Location:377 → 456
      RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
      cd16269
      Location:584 → 595
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:508 → 613
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04047.2 Q04047
    Q8IR16 Q8IR16
    X2JFR1 X2JFR1

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