rk rickets [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rkprovided by FlyBase
Official Full Name: ricketsprovided by FlyBase
Primary source: FLYBASE:FBgn0003255
Locus tag: Dmel_CG8930
See related: AllianceGenome:FB:FBgn0003255
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00180.13; CG8930; CT25644; DLGR-2; dlgr2; dLGR2; Dlgr2; DLgr2; DLGR2; dlgr2/rk; Dmel\CG8930; lgr2; Lgr2; LGR2; Rk; rk/CG8930
Summary: Enables neuropeptide receptor activity. Involved in several processes, including follicle cell of egg chamber development; intestinal stem cell homeostasis; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including central nervous system; epithelium; gut section; terminal tracheal cell; and wing. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4); LGR5 (leucine rich repeat containing G protein-coupled receptor 5); and LGR6 (leucine rich repeat containing G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34E5-34E6; 2-50 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13982743..14001248, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13982743..14001248, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Drosophila, rk function is required for the normal maturation of the fly's cuticular hydrocarbon (CH) profile, with flies mutant for rk function showing dramatically elevated levels of CHs. This effect is mostly abrogated by mutations in the Delta9 desaturase encoded by the desaturase1 gene, suggesting that desaturase1 acts downstream of rk.
Title: Regulation of cuticular hydrocarbon profile maturation by Drosophila tanning hormone, bursicon, and its interaction with desaturase activity.
2 alleles of the gene rickets (rk) encoding a G-protein-coupled receptor were isolated. The rk alleles result in border cell migration defects in a significant fraction of egg chambers. The rk receptor appears to regulate detachment and polarity of the border cell cluster coordinating processes within the cells of the cluster themselves.
Title: Signaling through the G-protein-coupled receptor Rickets is important for polarity, detachment, and migration of the border cells in Drosophila.
Membrane-anchored bursicon constructs were generated that can activate or inhibit membrane rk signaling.
Title: Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila G protein-coupled receptor rickets.
rickets appears to encode a component of the bursicon response pathway
Title: Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program.
Bursicon is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
Title: Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0415 (e-PCR)
- UniSTS:53685

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in border follicle cell delamination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chitin-based cuticle tanning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rickets

Names: CG8930-PA; glycoprotein hormone receptor II; glycoprotein-hormone-receptor-II; leucine-rich repeat-containing G protein-coupled receptor 2; rk-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13982743..14001248 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057354.3 → NP_476702.1 rickets [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476702.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KTA0, Q9NDI1

Related

FBpp0080183

Conserved Domains (6) summary

cd00116
Location:180 → 383

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:441 → 464

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:183 → 204

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:770 → 1017

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:487 → 545

LRR_8; Leucine rich repeat

cl21561
Location:764 → 892

7tm_4; Olfactory receptor