Meltrin meltrin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Meltrinprovided by FlyBase
Official Full Name: meltrinprovided by FlyBase
Primary source: FLYBASE:FBgn0265140
Locus tag: Dmel_CG7649
See related: AllianceGenome:FB:FBgn0265140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31314; CG31385; CG7649; CT23341; DMeltrin; Dmel\CG7649; FBgn0051314; meltrin; Neu3
Summary: Enables identical protein binding activity and metalloendopeptidase activity. Involved in membrane protein ectodomain proteolysis. Located in perivitelline space. Is expressed in several structures, including anlage in statu nascendi; gland; head epidermis primordium; imaginal disc; and nephrocyte. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cone-rod dystrophy 9; lung disease (multiple); osteoarthritis; and rhinitis. Orthologous to several human genes including ADAM12 (ADAM metallopeptidase domain 12); ADAM15 (ADAM metallopeptidase domain 15); and ADAM19 (ADAM metallopeptidase domain 19). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88C10-88D1; 3-56 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14664907..14697292, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10490629..10523014, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

highly restricted expression pattern during embryogenesis with at least two of the respective transcripts being present in a subpopulation of neuronal cells in the embryonic central nervous system
Title: The disintegrin and metalloprotease Meltrin from Drosophila forms oligomers via its protein binding domain and is regulated by the homeobox protein VND during embryonic development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1819 (e-PCR)
- UniSTS:46646

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perivitelline space	HDA more info	PubMed

General protein information

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Preferred Names: meltrin

Names: CG7649-PC; CG7649-PD; DMeltrin; Meltrin-PC; Meltrin-PD; Meltrin-like; Neu3; Neuroectoderm-expressed 3; dMeltrin-alpha

NP_001027575.1

EC 3.4.24.-

NP_001027576.2

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14664907..14697292 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001032403.2 → NP_001027575.1 meltrin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027575.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6QU65

Conserved Domains (5) summary

smart00608
Location:558 → 701

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:269 → 462

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:479 → 555

Disintegrin; Disintegrin

pfam01421
Location:269 → 464

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:64 → 174

Pep_M12B_propep; Reprolysin family propeptide
NM_001032404.3 → NP_001027576.2 meltrin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027576.2

Status: REVIEWED

UniProtKB/TrEMBL

Q400M8, Q86P79

Conserved Domains (5) summary

smart00608
Location:558 → 701

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:269 → 462

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:479 → 555

Disintegrin; Disintegrin

pfam01421
Location:269 → 464

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:64 → 174

Pep_M12B_propep; Reprolysin family propeptide