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    Opbp Optix-binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246618, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Opbpprovided by FlyBase
    Official Full Name
    Optix-binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050443
    Locus tag
    Dmel_CG30443
    See related
    AllianceGenome:FB:FBgn0050443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE37461; CG12397; CG30443; Dmel\CG30443; Obp; OBP
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and trunk mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Opbp in Genome Data Viewer
    Location:
    42C1-42C2; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6653217..6655267)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2540722..2542772)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Flavin-containing monooxygenase 2 Neighboring gene Death executioner Bcl-2 Neighboring gene geminin Neighboring gene scrambled

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms. Zhang H, et al. J Biol Chem, 2000 Sep 1. PMID 10811653
    2. CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers. Maksimenko OG, et al. Acta Naturae, 2021 Jan-Mar. PMID 33959385, Free PMC Article
    3. The N-Terminal Part of Drosophila CP190 Is a Platform for Interaction with Multiple Architectural Proteins. Golovnin A, et al. Int J Mol Sci, 2023 Nov 2. PMID 37958900, Free PMC Article
    4. Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. Kenyon KL, et al. Dev Dyn, 2005 Nov. PMID 15937930
    5. Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development. Kenyon KL, et al. Dev Biol, 2005 Oct 1. PMID 16125693

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Optix-binding protein
    Names
    CG30443-PA
    Opbp-PA
    optix binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6653217..6655267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165478.3 → NP_724479.1  Optix-binding protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6Y6, Q8IGS4
      Related
      FBpp0085444
      Conserved Domains (2) summary
      sd00017
      Location:301 → 321
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:316 → 336
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V6Y6 Q4V6Y6
    Q8IGS4 Q8IGS4

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