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    Nuf2 Nuf2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nuf2provided by FlyBase
    Official Full Name
    Nuf2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031886
    Locus tag
    Dmel_CG8902
    See related
    AllianceGenome:FB:FBgn0031886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.214; CG8902; Dmel\CG8902; dmNuf2; l(2)SH2 2276
    Summary
    Involved in mitotic metaphase chromosome alignment. Located in kinetochore. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nuf2 in Genome Data Viewer
    Location:
    27D7-27D7; 2-24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7064431..7065837, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7064431..7065837, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene caper Neighboring gene milton Neighboring gene Menin 1 Neighboring gene Male specific transcript 27D Neighboring gene Suppressor of exocyst mutations 1 Neighboring gene UDP-glycosyltransferase family 307 member A1 Neighboring gene PDGF- and VEGF-related factor 2 Neighboring gene long non-coding RNA:CR44611

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Meraldi P, et al. Genome Biol, 2006. PMID 16563186, Free PMC Article
    2. POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments. Moutinho-Santos T, et al. J Cell Sci, 2012 Feb 1. PMID 22389397
    3. Drosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. Venkei Z, et al. Genetics, 2011 Jan. PMID 20980244, Free PMC Article
    4. Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore. Venkei Z, et al. Open Biol, 2012 Feb. PMID 22645658, Free PMC Article
    5. Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation. Pellacani C, et al. Elife, 2018 Nov 26. PMID 30475206, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nuf2
    Names
    CG8902-PA
    Nuf2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7064431..7065837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135252.4 → NP_609096.2  Nuf2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609096.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D9, Q9VM45
      Related
      FBpp0079052
      Conserved Domains (1) summary
      pfam03800
      Location:20 → 114
      Nuf2; Nuf2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960D9 Q960D9
    Q9VM45 Q9VM45

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