Zfp30 zinc finger protein 30 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp30provided by MGI
Official Full Name: zinc finger protein 30provided by MGI
Primary source: MGI:MGI:99178
See related: Ensembl:ENSMUSG00000047473 AllianceGenome:MGI:99178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp-30; 2610306P15Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human ZFP30 (ZFP30 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E14 (RPKM 3.8), CNS E18 (RPKM 3.4) and 26 other tissues See more
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Genomic context

Location:: 7 B1; 7 17.26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29483393..29494128)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (29783968..29794703)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Baseline and innate immune response characterization of a Zfp30 knockout mouse strain.
Title: Baseline and innate immune response characterization of a Zfp30 knockout mouse strain.
Using murine and human in vitro and in vivo models, study demonstrated that ZFP30 promotes adipogenesis by directly targeting and activating a retrotransposon-derived Pparg2 enhancer. Through mechanistic studies, study further show that ZFP30 recruits the co-regulator KAP1, which acts as a ZFP30 co-activator in this adipogenic context.
Title: ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer.
Data indicate zinc finger protein 148 (ZFP148) as a transcription factor that differentially binds to the zinc finger protein 30 protein (Zfp30) promoter region harboring rs51434084.
Title: Differential Regulation of Zfp30 Expression in Murine Airway Epithelia Through Altered Binding of ZFP148 to rs51434084.
Zfp30 is expressed in airway epithelia in the normal mouse lung and Zfp30 expression in vitro affects CXCL1 responses to an immune stimulus.
Title: Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation in murine lung.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360207.1 → NP_001347136.1 zinc finger protein 30 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC156934

Conserved Domains (3) summary

smart00349
Location:39 → 100

KRAB; krueppel associated box

COG5048
Location:196 → 556

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:487 → 507

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001360208.1 → NP_001347137.1 zinc finger protein 30 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.

Source sequence(s)

AC156934

Conserved Domains (3) summary

smart00349
Location:39 → 99

KRAB; krueppel associated box

COG5048
Location:195 → 555

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:486 → 506

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001360209.1 → NP_001347138.1 zinc finger protein 30 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal aa compared to isoform a.

Source sequence(s)

AC156934

Conserved Domains (3) summary

smart00349
Location:21 → 81

KRAB; krueppel associated box

COG5048
Location:177 → 537

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:468 → 488

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001360210.1 → NP_001347139.1 zinc finger protein 30 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5, 6, and 7 all encode the same isoform (e).

Source sequence(s)

AC156934

Consensus CDS

CCDS90199.1

UniProtKB/TrEMBL

D3Z614

Conserved Domains (2) summary

COG5048
Location:97 → 457

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:388 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001360212.1 → NP_001347141.1 zinc finger protein 30 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5, 6, and 7 all encode the same isoform (e).

Source sequence(s)

AC156934

Consensus CDS

CCDS90199.1

UniProtKB/TrEMBL

D3Z614

Conserved Domains (2) summary

COG5048
Location:97 → 457

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:388 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001360213.1 → NP_001347142.1 zinc finger protein 30 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 5, 6, and 7 all encode the same isoform (e).

Source sequence(s)

AC156934, AK032058

Consensus CDS

CCDS90199.1

UniProtKB/TrEMBL

D3Z614

Related

ENSMUSP00000113426.2, ENSMUST00000122387.2

Conserved Domains (2) summary

COG5048
Location:97 → 457

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:388 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_013705.2 → NP_038733.1 zinc finger protein 30 isoform c

See identical proteins and their annotated locations for NP_038733.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AC156934, Z30174

Consensus CDS

CCDS21075.1

UniProtKB/TrEMBL

Q78FW7

Related

ENSMUSP00000032803.6, ENSMUST00000032803.12

Conserved Domains (5) summary

smart00349
Location:21 → 82

KRAB; krueppel associated box

COG5048
Location:178 → 538

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:469 → 489

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:21 → 60

KRAB; KRAB box

pfam13465
Location:286 → 310

zf-H2C2_2; Zinc-finger double domain