Afm afamin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Afmprovided by MGI
Official Full Name: afaminprovided by MGI
Primary source: MGI:MGI:2429409
See related: Ensembl:ENSMUSG00000029369 AllianceGenome:MGI:2429409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Alf; alpha-Alb
Summary: Predicted to enable vitamin E binding activity. Predicted to be involved in protein stabilization; protein transport within extracellular region; and vitamin transport. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; liver; and metanephros. Orthologous to human AFM (afamin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 42.9), liver E18 (RPKM 22.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 44.78 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (90666808..90701403)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (90518949..90553544)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Afamin is one of osteoclast-derived chemokines that affect preosteoblasts through the activation of the Akt-signaling pathway.
Title: Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway.
Data indicate that HNF1alpha is a more potent activator of AFM promoter than is HNF1beta.
Title: The mouse alpha-albumin (afamin) promoter is differentially regulated by hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4)

General gene information

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Markers

Afm (e-PCR), detects polymorphism
- UniSTS:527208

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables vitamin E binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin E binding	ISO Inferred from Sequence Orthology more info
enables vitamin E binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport within extracellular region	ISO Inferred from Sequence Orthology more info
involved_in protein transport within extracellular region	ISS Inferred from Sequence or Structural Similarity more info
involved_in vitamin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin transport	ISO Inferred from Sequence Orthology more info
involved_in vitamin transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: afamin

Names: alpha-albumin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145146.3 → NP_660128.2 afamin precursor

See identical proteins and their annotated locations for NP_660128.2

Status: VALIDATED

Source sequence(s)

AC135240, AC140220

Consensus CDS

CCDS39141.1

UniProtKB/Swiss-Prot

O89020, Q3UNV0, Q497E6, Q8R0J9

Related

ENSMUSP00000108804.3, ENSMUST00000113179.9

Conserved Domains (2) summary

cd00015
Location:413 → 596

ALBUMIN; Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; ...

pfam00273
Location:33 → 202

Serum_albumin; Serum albumin family