Frat2 frequently rearranged in advanced T cell lymphomas 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Frat2provided by MGI
Official Full Name: frequently rearranged in advanced T cell lymphomas 2provided by MGI
Primary source: MGI:MGI:2673967
See related: Ensembl:ENSMUSG00000047604 AllianceGenome:MGI:2673967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human FRAT2 (FRAT regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 35.33 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41834411..41836571, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41845972..41848132, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM98 reduces FRAT2 protein levels and, accordingly, inhibits the FRAT2-mediated induction of ss-catenin/TCF signalling.
Title: TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling.
Data show that MLL fusion oncogenes maintain leukemia-associated Rac GTPases activity by regulating Frat gene expression, specifically Frat2.
Title: Frat2 mediates the oncogenic activation of Rac by MLL fusions.
Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.
Title: Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548357

NoName (e-PCR)
- UniSTS:548358

Frat2 (e-PCR), detects polymorphism
- UniSTS:506905

AU048745 (e-PCR)
- UniSTS:145195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GSK-3-binding protein FRAT2

Names: FRAT-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.