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    Gpr180 G protein-coupled receptor 180 [ Mus musculus (house mouse) ]

    Gene ID: 58245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr180provided by MGI
    Official Full Name
    G protein-coupled receptor 180provided by MGI
    Primary source
    MGI:MGI:1930949
    See related
    Ensembl:ENSMUSG00000022131 AllianceGenome:MGI:1930949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Itr; E130016I23Rik
    Summary
    Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Is expressed in embryo. Orthologous to human GPR180 (G protein-coupled receptor 180). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 17.9), limb E14.5 (RPKM 15.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr180 in Genome Data Viewer
    Location:
    14 E4; 14 61.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (118374513..118401644)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118137105..118164232)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7351 Neighboring gene nuclear encoded tRNA pheylalanine 5 (anticodon GAA) Neighboring gene predicted gene, 31633 Neighboring gene STARR-seq mESC enhancer starr_37634 Neighboring gene TDP-glucose 4,6-dehydratase Neighboring gene STARR-positive B cell enhancer ABC_E7352 Neighboring gene predicted gene 4674 Neighboring gene RIKEN cDNA 4933431J24 gene Neighboring gene predicted gene, 31981

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway. Zhang Y, et al. Nutrients, 2023 Apr 11. PMID 37111058, Free PMC Article
    2. Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor. Tsukada S, et al. Circulation, 2003 Jan 21. PMID 12538434
    3. GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1. Balazova L, et al. Nat Commun, 2021 Dec 8. PMID 34880217, Free PMC Article
    4. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway.
      Title: Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway.
    2. GPR180 is a component of TGFbeta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
      Title: GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein GPR180
    Names
    intimal thickness-related receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021434.5 → NP_067409.2  integral membrane protein GPR180 precursor

      See identical proteins and their annotated locations for NP_067409.2

      Status: VALIDATED

      Source sequence(s)
      AC108833, AK053422, CX210992
      Consensus CDS
      CCDS27333.1
      UniProtKB/Swiss-Prot
      Q8BPS4, Q9JJG1
      Related
      ENSMUSP00000022728.3, ENSMUST00000022728.4
      Conserved Domains (1) summary
      pfam10192
      Location:144 → 406
      GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      118374513..118401644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247903.1 → XP_030103763.1  integral membrane protein GPR180 isoform X2

      Conserved Domains (1) summary
      pfam10192
      Location:1 → 258
      GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

    2. XM_006519335.4 → XP_006519398.1  integral membrane protein GPR180 isoform X1

      Conserved Domains (1) summary
      pfam10192
      Location:99 → 339
      GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

    RNA

    1. XR_383197.5 RNA Sequence

    2. XR_003950877.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPS4.1 GenPept UniProtKB/Swiss-Prot:Q8BPS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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