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    Tmem253 transmembrane protein 253 [ Mus musculus (house mouse) ]

    Gene ID: 619301, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem253provided by MGI
    Official Full Name
    transmembrane protein 253provided by MGI
    Primary source
    MGI:MGI:3588246
    See related
    Ensembl:ENSMUSG00000072571 AllianceGenome:MGI:3588246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G630016D24Rik
    Summary
    Predicted to be located in membrane. Orthologous to human TMEM253 (transmembrane protein 253). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 27.4), large intestine adult (RPKM 19.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem253 in Genome Data Viewer
    Location:
    14 C2; 14 26.77 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52252309..52257244)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52014852..52019787)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 6a (zeta) pseudogene Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene predicted gene, 16617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628339-52628522 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628697-52628806 Neighboring gene zinc finger protein 219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52639962-52640145 Neighboring gene STARR-seq mESC enhancer starr_36687 Neighboring gene olfactory receptor family 5 subfamily AU member 1 Neighboring gene STARR-seq mESC enhancer starr_36689 Neighboring gene STARR-seq mESC enhancer starr_36690 Neighboring gene STARR-seq mESC enhancer starr_36694 Neighboring gene predicted gene, 22354

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 253
    Names
    tranmembrane protein 253
    transmembrane protein C14orf176 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033805.3 → NP_001028977.1  transmembrane protein 253

      See identical proteins and their annotated locations for NP_001028977.1

      Status: VALIDATED

      Source sequence(s)
      AK144313
      Consensus CDS
      CCDS27049.1
      UniProtKB/Swiss-Prot
      Q3UNB8
      Related
      ENSMUSP00000098203.3, ENSMUST00000100638.4
      Conserved Domains (1) summary
      pfam04103
      Location:34 → 113
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52252309..52257244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245128.3 → XP_011243430.1  transmembrane protein 253 isoform X1

      See identical proteins and their annotated locations for XP_011243430.1

      UniProtKB/Swiss-Prot
      Q3UNB8
      Conserved Domains (1) summary
      pfam04103
      Location:34 → 113
      CD20; CD20-like family

    2. XM_017316105.3 → XP_017171594.1  transmembrane protein 253 isoform X1

      UniProtKB/Swiss-Prot
      Q3UNB8

    3. XM_030247905.2 → XP_030103765.1  transmembrane protein 253 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BR52
      Related
      ENSMUSP00000154460.2, ENSMUST00000227295.2

    4. XM_036158775.1 → XP_036014668.1  transmembrane protein 253 isoform X1

      UniProtKB/Swiss-Prot
      Q3UNB8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UNB8.1 GenPept UniProtKB/Swiss-Prot:Q3UNB8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials