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    Pxn Peroxidasin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38326, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pxnprovided by FlyBase
    Official Full Name
    Peroxidasinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011828
    Locus tag
    Dmel_CG12002
    See related
    AllianceGenome:FB:FBgn0011828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12002; CT1239; Dmel\CG12002; DmPxd-a; Dpxn; HPX4; pxn
    Summary
    Predicted to enable peroxidase activity. Involved in basement membrane assembly; collagen fibril organization; and phagocytosis. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space. Is expressed in several structures, including adult brain; circulatory system primordium; embryonic/larval lymph gland; hemocyte; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; anterior segment dysgenesis 7; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including PXDN (peroxidasin) and PXDNL (peroxidasin like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pxn in Genome Data Viewer
    Location:
    62E7-62E7; 3-3 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2601455..2630064, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2601455..2630064, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45981 Neighboring gene long non-coding RNA:CR45982 Neighboring gene long non-coding RNA:CR45660 Neighboring gene uncharacterized protein Neighboring gene MEP-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxidasin: a novel enzyme-matrix protein of Drosophila development. Nelson RE, et al. EMBO J, 1994 Aug 1. PMID 8062820, Free PMC Article
    2. Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults. Peebles KE, et al. Matrix Biol, 2024 Jan. PMID 38000777,
    3. Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. Babcock DT, et al. Proc Natl Acad Sci U S A, 2008 Jul 22. PMID 18632567, Free PMC Article
    4. DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking. Howard AM, et al. J Cell Sci, 2019 Apr 8. PMID 30837285, Free PMC Article
    5. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. McCall AS, et al. Cell, 2014 Jun 5. PMID 24906154, Free PMC Article

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
      Title: Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on peroxide as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in basement membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peroxidasin
    Names
    CG12002-PA
    CG12002-PB
    CG12002-PC
    CG12002-PD
    CG12002-PE
    Pxn-PA
    Pxn-PB
    Pxn-PC
    Pxn-PD
    Pxn-PE
    peroxydasin
    protein X
    NP_523891.2
    NP_728759.1
    NP_995975.1
    NP_995976.1
    NP_995977.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2601455..2630064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079167.5 → NP_523891.2  peroxidasin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523891.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23991, Q960D1, Q961K8, Q9VZZ4
      UniProtKB/TrEMBL
      D2NUH5, E0R979
      Related
      FBpp0072828
      Conserved Domains (11) summary
      cd00096
      Location:384 → 451
      Ig; Immunoglobulin domain
      cd09826
      Location:898 → 1338
      peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
      smart00410
      Location:242 → 325
      IG_like; Immunoglobulin like
      cd00116
      Location:51 → 161
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:458 → 546
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:54 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00093
      Location:1465 → 1523
      VWC; von Willebrand factor type C domain
      pfam03098
      Location:777 → 1317
      An_peroxidase; Animal haem peroxidase
      pfam12799
      Location:148 → 185
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:55 → 112
      LRR_8; Leucine rich repeat
      cl11960
      Location:240 → 325
      Ig; Immunoglobulin domain

    2. NM_206255.3 → NP_995977.1  peroxidasin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995977.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23991, Q960D1, Q961K8, Q9VZZ4
      UniProtKB/TrEMBL
      D2NUH5, E0R979
      Conserved Domains (11) summary
      cd00096
      Location:384 → 451
      Ig; Immunoglobulin domain
      cd09826
      Location:898 → 1338
      peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
      smart00410
      Location:242 → 325
      IG_like; Immunoglobulin like
      cd00116
      Location:51 → 161
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:458 → 546
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:54 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00093
      Location:1465 → 1523
      VWC; von Willebrand factor type C domain
      pfam03098
      Location:777 → 1317
      An_peroxidase; Animal haem peroxidase
      pfam12799
      Location:148 → 185
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:55 → 112
      LRR_8; Leucine rich repeat
      cl11960
      Location:240 → 325
      Ig; Immunoglobulin domain

    3. NM_206254.3 → NP_995976.1  peroxidasin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995976.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23991, Q960D1, Q961K8, Q9VZZ4
      UniProtKB/TrEMBL
      D2NUH5, E0R979
      Conserved Domains (11) summary
      cd00096
      Location:384 → 451
      Ig; Immunoglobulin domain
      cd09826
      Location:898 → 1338
      peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
      smart00410
      Location:242 → 325
      IG_like; Immunoglobulin like
      cd00116
      Location:51 → 161
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:458 → 546
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:54 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00093
      Location:1465 → 1523
      VWC; von Willebrand factor type C domain
      pfam03098
      Location:777 → 1317
      An_peroxidase; Animal haem peroxidase
      pfam12799
      Location:148 → 185
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:55 → 112
      LRR_8; Leucine rich repeat
      cl11960
      Location:240 → 325
      Ig; Immunoglobulin domain

    4. NM_206253.3 → NP_995975.1  peroxidasin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23991, Q960D1, Q961K8, Q9VZZ4
      UniProtKB/TrEMBL
      D2NUH5, E0R979
      Conserved Domains (11) summary
      cd00096
      Location:384 → 451
      Ig; Immunoglobulin domain
      cd09826
      Location:898 → 1338
      peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
      smart00410
      Location:242 → 325
      IG_like; Immunoglobulin like
      cd00116
      Location:51 → 161
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:458 → 546
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:54 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00093
      Location:1465 → 1523
      VWC; von Willebrand factor type C domain
      pfam03098
      Location:777 → 1317
      An_peroxidase; Animal haem peroxidase
      pfam12799
      Location:148 → 185
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:55 → 112
      LRR_8; Leucine rich repeat
      cl11960
      Location:240 → 325
      Ig; Immunoglobulin domain

    5. NM_167957.3 → NP_728759.1  peroxidasin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5A7N1
      Related
      FBpp0072827
      Conserved Domains (8) summary
      cd00096
      Location:384 → 451
      Ig; Immunoglobulin domain
      smart00013
      Location:26 → 55
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:242 → 325
      IG_like; Immunoglobulin like
      cd00116
      Location:51 → 161
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:366 → 450
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:54 → 77
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:55 → 112
      LRR_8; Leucine rich repeat
      cl11960
      Location:240 → 325
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZZ4.1 Q9VZZ4

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