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    Tango11 Transport and Golgi organization 11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246596, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tango11provided by FlyBase
    Official Full Name
    Transport and Golgi organization 11provided by FlyBase
    Primary source
    FLYBASE:FBgn0050404
    Locus tag
    Dmel_CG30404
    See related
    AllianceGenome:FB:FBgn0050404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1F11; BcDNA:LD22567; BEST:LD33633; CG30404; Dmel\CG30404; tango11; TANGO11
    Summary
    Involved in mitochondrial fission and protein secretion. Located in endoplasmic reticulum membrane. Is expressed in adult head; gonad; and organism. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 2. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Tango11 in Genome Data Viewer
    Location:
    57F10-57F10; 2-96 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21716780..21719963, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17604285..17607468, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene High mobility group protein D Neighboring gene long non-coding RNA:CR44749 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lamin B receptor Neighboring gene long non-coding RNA:CR44750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Finding differentially expressed regions of arbitrary length in quantitative genomic data based on marked point process model. Hatsuda H. Bioinformatics, 2012 Sep 15. PMID 22962492, Free PMC Article
    2. D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries. Debattisti V, et al. Mol Cell Neurosci, 2013 Jul. PMID 22940086
    3. Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Au WH, et al. Life Sci Alliance, 2024 Sep. PMID 38906677, Free PMC Article
    4. TDP-43 and PINK1 mediate CHCHD10(S59L) mutation-induced defects in Drosophila and in vitro. Baek M, et al. Nat Commun, 2021 Mar 26. PMID 33772006, Free PMC Article
    5. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Gandre-Babbe S, et al. Mol Biol Cell, 2008 Jun. PMID 18353969, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peroxisome fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transport and golgi organization 11
    Names
    CG30404-PA
    CG30404-PB
    CG30404-PC
    Tango11-PA
    Tango11-PB
    Tango11-PC
    anon-fast-evolving-1F11
    tango11
    transport and golgi organization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21716780..21719963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166481.3 → NP_726111.1  transport and golgi organization 11, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961C9
      UniProtKB/TrEMBL
      E2QCK0
      Related
      FBpp0071660
      Conserved Domains (1) summary
      pfam05644
      Location:15 → 276
      Miff; Mitochondrial and peroxisomal fission factor Mff

    2. NM_166482.2 → NP_726112.1  transport and golgi organization 11, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961C9
      UniProtKB/TrEMBL
      E2QCK0
      Related
      FBpp0071661
      Conserved Domains (1) summary
      pfam05644
      Location:15 → 276
      Miff; Mitochondrial and peroxisomal fission factor Mff

    3. NM_001299768.1 → NP_001286697.1  transport and golgi organization 11, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG59
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 92
      Miff; Mitochondrial and peroxisomal fission factor Mff
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG59 A0A0B4LG59
    E2QCK0 E2QCK0
    Q961C9.1 Q961C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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