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    stas Stasimon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stasprovided by FlyBase
    Official Full Name
    Stasimonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030850
    Locus tag
    Dmel_CG8408
    See related
    AllianceGenome:FB:FBgn0030850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8408; Dmel\CG8408; Tmem41b
    Summary
    Involved in positive regulation of cholinergic synaptic transmission. Predicted to be active in endoplasmic reticulum membrane. Is expressed in organism. Orthologous to human TMEM41B (transmembrane protein 41B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stas in Genome Data Viewer
    Location:
    16B9-16B9; 1-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17623221..17627895, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17517254..17521928, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene X11L Neighboring gene uncharacterized protein Neighboring gene corolla

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article
    2. Identification of germ plasm-enriched mRNAs in Drosophila melanogaster by the cDNA microarray technique. Szuperák M, et al. Gene Expr Patterns, 2005 Jun. PMID 15939385
    3. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article
    4. Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases. Charng WL, et al. Curr Opin Neurobiol, 2014 Aug. PMID 24762652, Free PMC Article
    5. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Praveen K, et al. Cell Rep, 2012 Jun 28. PMID 22813737, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stasimon
    Names
    CG8408-PA
    CG8408-PB
    stas-PA
    stas-PB
    stymied in smn

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17623221..17627895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132997.3 → NP_573225.1  stasimon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z102, Q95RT5, Q9VX39
      Related
      FBpp0074261
      Conserved Domains (1) summary
      pfam09335
      Location:157 → 276
      SNARE_assoc; SNARE associated Golgi protein

    2. NM_001144745.2 → NP_001138217.1  stasimon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138217.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX39
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX39.2 Q9VX39

    Gene LinkOut

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