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    CREG Cellular Repressor of E1A-stimulated Genes [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CREGprovided by FlyBase
    Official Full Name
    Cellular Repressor of E1A-stimulated Genesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025456
    Locus tag
    Dmel_CG5413
    See related
    AllianceGenome:FB:FBgn0025456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP11958; CG5413; creg; dCREG; Dmel\CG5413
    Summary
    Enables TBP-class protein binding activity and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in extracellular space. Is expressed in adult head and adult heart. Orthologous to several human genes including CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CREG in Genome Data Viewer
    Location:
    90A5-90A5; 3-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17393272..17394640, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13218994..13220362, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Brf RNA polymerase III subunit Neighboring gene long non-coding RNA:CR43196 Neighboring gene lute Neighboring gene antisense RNA:CR44160 Neighboring gene sds22 Neighboring gene Sur-8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development. Kowalewski-Nimmerfall E, et al. Biochim Biophys Acta, 2014 Dec. PMID 25173815, Free PMC Article
    2. Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers. Genç Ö, et al. Elife, 2020 Jul 1. PMID 32609087, Free PMC Article
    3. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Veal E, et al. Mol Cell Biol, 1998 Sep. PMID 9710587, Free PMC Article
    4. Identification and characterization of a juvenile hormone response element and its binding proteins. Li Y, et al. J Biol Chem, 2007 Dec 28. PMID 17956872, Free PMC Article
    5. Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila. Spierer AN, et al. PLoS Genet, 2021 Mar. PMID 33735180, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cellular repressor of E1A-stimulated genes
    Names
    CG5413-PA
    CG5413-PB
    CG5413-PC
    CG5413-PD
    CREG-PA
    CREG-PB
    CREG-PC
    CREG-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17393272..17394640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260223.1 → NP_001247152.1  cellular repressor of E1A-stimulated genes, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76804, Q9VEK7
      Conserved Domains (1) summary
      pfam13883
      Location:39 → 208
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    2. NM_169756.2 → NP_732229.1  cellular repressor of E1A-stimulated genes, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76804, Q9VEK7
      Related
      FBpp0088836
      Conserved Domains (1) summary
      pfam13883
      Location:39 → 208
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    3. NM_169757.4 → NP_732230.1  cellular repressor of E1A-stimulated genes, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGZ3, Q8IN97
      Related
      FBpp0088834
      Conserved Domains (1) summary
      pfam13883
      Location:39 → 150
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    4. NM_079661.5 → NP_524385.2  cellular repressor of E1A-stimulated genes, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524385.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76804, Q9VEK7
      Related
      FBpp0088835
      Conserved Domains (1) summary
      pfam13883
      Location:39 → 208
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76804 O76804
    Q8IGZ3 Q8IGZ3
    Q8IN97 Q8IN97
    Q9VEK7 Q9VEK7

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