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    CG8188 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8188provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030863
    Locus tag
    Dmel_CG8188
    See related
    AllianceGenome:FB:FBgn0030863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8188; Ubc; Ube2S
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Involved in anaphase-promoting complex-dependent catabolic process and exit from mitosis. Predicted to be active in nucleus. Orthologous to human UBE2S (ubiquitin conjugating enzyme E2 S). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8188 in Genome Data Viewer
    Location:
    16C1-16C1; 1-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17698917..17703024, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17592950..17597057, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene beta Spectrin Neighboring gene uncharacterized protein Neighboring gene chascon Neighboring gene par-6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Ali YO, et al. Hum Mol Genet, 2012 Jan 15. PMID 21965302, Free PMC Article
    2. Photic signaling by cryptochrome in the Drosophila circadian system. Lin FJ, et al. Mol Cell Biol, 2001 Nov. PMID 11585911, Free PMC Article
    3. A critical assessment of storytelling: gene ontology categories and the importance of validating genomic scans. Pavlidis P, et al. Mol Biol Evol, 2012 Oct. PMID 22617950
    4. Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein. Kaplow ME, et al. Genetics, 2008 Apr. PMID 18430931, Free PMC Article
    5. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Petronczki M, et al. Nat Cell Biol, 2001 Jan. PMID 11146625

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8188-PA
    CG8188-PB
    CG8188-PC
    CG8188-PD
    NP_001033852.1
    NP_001285383.1
    NP_001285384.1
    NP_573237.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17698917..17703024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298455.1 → NP_001285384.1  uncharacterized protein Dmel_CG8188, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285384.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX25
      UniProtKB/TrEMBL
      X2JFX0
      Conserved Domains (2) summary
      COG5078
      Location:12 → 159
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:16 → 155
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_133009.3 → NP_573237.2  uncharacterized protein Dmel_CG8188, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573237.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX25
      UniProtKB/TrEMBL
      X2JFX0
      Related
      FBpp0074250
      Conserved Domains (2) summary
      COG5078
      Location:12 → 159
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:16 → 155
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_001298454.1 → NP_001285383.1  uncharacterized protein Dmel_CG8188, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX25
      UniProtKB/TrEMBL
      X2JFX0
      Conserved Domains (2) summary
      COG5078
      Location:12 → 159
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:16 → 155
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_001038763.2 → NP_001033852.1  uncharacterized protein Dmel_CG8188, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VX25
      UniProtKB/TrEMBL
      X2JFX0
      Conserved Domains (2) summary
      COG5078
      Location:12 → 159
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:16 → 155
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX25.2 Q9VX25
    X2JFX0 X2JFX0

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