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    CG12926 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12926provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033437
    Locus tag
    Dmel_CG12926
    See related
    AllianceGenome:FB:FBgn0033437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12926
    Summary
    Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head; anterior endoderm anlage; anterior midgut primordium; embryonic/larval midgut; and posterior midgut primordium. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12926 in Genome Data Viewer
    Location:
    45F6-45F6; 2-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9608128..9610290, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5495633..5497795, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44285 Neighboring gene antisense RNA:CR44069 Neighboring gene Glutathione S transferase T1 Neighboring gene Glutathione S transferase T2 Neighboring gene Matrix metalloproteinase 2 Neighboring gene mir-307b stem loop Neighboring gene mir-307a stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dRTEL1 is essential for the maintenance of Drosophila male germline stem cells. Yang Y, et al. PLoS Genet, 2021 Oct. PMID 34644293, Free PMC Article
    2. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Yin J, et al. Nat Commun, 2021 Apr 23. PMID 33893307, Free PMC Article
    3. A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Huet F, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096187, Free PMC Article
    4. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. Page RM, et al. J Neurosci, 2012 Dec 12. PMID 23238734, Free PMC Article
    5. A neurogenetic mechanism of experience-dependent suppression of aggression. Ishii K, et al. Sci Adv, 2022 Sep 9. PMID 36070378, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12926-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9608128..9610290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136666.4 → NP_610510.2  uncharacterized protein Dmel_CG12926 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610510.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7X8, Q8SXZ7
      Related
      FBpp0087586
      Conserved Domains (2) summary
      smart01100
      Location:32 → 77
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:117 → 254
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7X8 A1Z7X8
    Q8SXZ7 Q8SXZ7

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