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    narya narya [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32932, updated on 9-Dec-2024

    Summary

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    Official Symbol
    naryaprovided by FlyBase
    Official Full Name
    naryaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031018
    Locus tag
    Dmel_CG12200
    See related
    AllianceGenome:FB:FBgn0031018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12200; Dmel\CG12200; Narya
    Summary
    Predicted to enable SUMO transferase activity and zinc ion binding activity. Involved in positive regulation of meiotic DNA double-strand break formation. Located in site of double-strand break. Human ortholog(s) of this gene implicated in spermatogenic failure 62. Orthologous to several human genes including RNF212B (ring finger protein 212B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See narya in Genome Data Viewer
    Location:
    18C7-18C7; 1-62 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19475063..19476055)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19369096..19370088)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha7 Neighboring gene kekkon 5 Neighboring gene long non-coding RNA:CR43260 Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 15/16 Neighboring gene mitochondrial ribosomal protein S14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance. Lake CM, et al. Proc Natl Acad Sci U S A, 2024 Sep 3. PMID 39190345, Free PMC Article
    2. A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure. Gershoni M, et al. HGG Adv, 2023 Jul 13. PMID 37124137, Free PMC Article
    3. Sex-dependent gene expression and evolution of the Drosophila transcriptome. Ranz JM, et al. Science, 2003 Jun 13. PMID 12805547
    4. Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. Beumer KJ, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979928, Free PMC Article
    5. Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster. Lake CM, et al. PLoS Genet, 2019 Jan. PMID 30615609, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of meiotic DNA double-strand break formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    narya
    Names
    CG12200-PA
    narya-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19475063..19476055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133155.4 → NP_573383.1  narya [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K4P2, Q9VWI4
      Related
      FBpp0074479
      Conserved Domains (1) summary
      pfam14634
      Location:5 → 49
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWI4.1 Q9VWI4

    Gene LinkOut

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