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    Sez6 seizure related 6 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192247, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sez6provided by RGD
    Official Full Name
    seizure related 6 homologprovided by RGD
    Primary source
    RGD:619780
    See related
    EnsemblRapid:ENSRNOG00000009350 AllianceGenome:RGD:619780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of dendrite development; regulation of protein kinase C signaling; and synapse maturation. Predicted to act upstream of or within several processes, including activation of protein kinase C activity; cerebellar Purkinje cell layer development; and excitatory postsynaptic potential. Predicted to be located in apical dendrite and perinuclear region of cytoplasm. Predicted to be active in dendrite; endoplasmic reticulum; and neuronal cell body. Orthologous to human SEZ6 (seizure related 6 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 117.8), Liver (RPKM 26.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sez6 in Genome Data Viewer
    Location:
    10q24-q25
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63317065..63366733)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62818931..62868686)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (64865802..64915461, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myosin XVIIIa Neighboring gene uncharacterized LOC102557169 Neighboring gene uncharacterized LOC102551552 Neighboring gene pipecolic acid and sarcosine oxidase Neighboring gene uncharacterized LOC134480828 Neighboring gene PHD finger protein 12 Neighboring gene dehydrogenase/reductase 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sez-6 may play an important role in neurite outgrowth through the PKCgamma signaling pathways. Zhang J, et al. Z Naturforsch C J Biosci, 2011 Nov-Dec. PMID 22351987
    2. Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Gunnersen JM, et al. Neuron, 2007 Nov 21. PMID 18031681
    3. Cloning and expression of SEZ-6, a brain-specific and seizure-related cDNA. Shimizu-Nishikawa K, et al. Brain Res Mol Brain Res, 1995 Feb. PMID 7723619
    4. Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent retina and the consequence of gene deletion. Gunnersen JM, et al. PLoS One, 2009 Aug 7. PMID 19662096, Free PMC Article
    5. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. Miyazaki T, et al. FEBS Lett, 2006 Jul 24. PMID 16814779

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein kinase C signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendritic shaft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    seizure protein 6 homolog
    Names
    seizure related gene 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105754.2 → NP_001099224.2  seizure protein 6 homolog precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1MA42
      Conserved Domains (4) summary
      cd00033
      Location:708 → 764
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:769 → 828
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      cd00041
      Location:414 → 524
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:530 → 587
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63317065..63366733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268377.1 → XP_063124447.1  seizure protein 6 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRZ3
      Related
      ENSRNOP00000040374.5, ENSRNOT00000048543.7

    2. XM_006246954.5 → XP_006247016.1  seizure protein 6 homolog isoform X2

      Conserved Domains (4) summary
      cd00033
      Location:708 → 764
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:769 → 828
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      cd00041
      Location:414 → 524
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:530 → 587
      Sushi; Sushi repeat (SCR repeat)

    3. XM_063268378.1 → XP_063124448.1  seizure protein 6 homolog isoform X3

    4. XM_063268379.1 → XP_063124449.1  seizure protein 6 homolog isoform X4

      Related
      ENSRNOP00000079695.2, ENSRNOT00000111113.2

    5. XM_017596981.3 → XP_017452470.1  seizure protein 6 homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZN57

    6. XM_006246953.5 → XP_006247015.1  seizure protein 6 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRZ3
      Conserved Domains (4) summary
      cd00033
      Location:708 → 764
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:769 → 828
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      cd00041
      Location:414 → 524
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:530 → 587
      Sushi; Sushi repeat (SCR repeat)
    Nucleotide Protein Strain
    Heading Accession and Version

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