Cit citron rho-interacting serine/threonine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Citprovided by RGD
Official Full Name: citron rho-interacting serine/threonine kinaseprovided by RGD
Primary source: RGD:70878
See related: EnsemblRapid:ENSRNOG00000001143 AllianceGenome:RGD:70878
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CRIK
Summary: Enables scaffold protein binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; gamma-aminobutyric acid signaling pathway; and postsynapse organization. Located in several cellular components, including GABA-ergic synapse; cleavage furrow; and postsynaptic density. Used to study epilepsy and microcephaly. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 234.6), Brain (RPKM 74.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (46263881..46425642, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (40603073..40764846, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (46334669..46494152, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CitK is not required for a subset of RPCs before E14, but is necessary for RPC survival post E14.
Title: Loss of citron kinase affects a subset of progenitor cells that alters late but not early neurogenesis in the developing rat retina.
Citron-K regulates actin polymerization downstream of RhoA and may offer a potentially novel therapeutic approach for promoting central nervous system axon regeneration.
Title: Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA.
This study demonistrated that Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons.
Title: Failed cytokinesis of neural progenitors in citron kinase-deficient rats leads to multiciliated neurons.
Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments.
Title: The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments.
Citron-N is found with the Golgi apparatus of hippocampal neurons in culture. Suppression of the whole protein or expression of a mutant form lacking the Rho-binding activity results in dispersion of the Golgi apparatus.
Title: Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation.
Postnatal neurogenesis in the dentate gyrus is eliminated by loss of citron-K function, suggesting that a citron-K-dependent progenitor lineage forms the postnatal neuronal progenitor population in the dentate gyrus.
Title: Citron kinase is required for postnatal neurogenesis in the hippocampus.
Deletion mutants mediate somatodendritic targeting, while regions in the C-terminal half of citron are responsible for precise alignment of postsynaptic citron clusters at sites apposing presynaptic boutons.
Title: Targeting and clustering citron to synapses.
Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase and functions in the control of G(2)/M transition in the hepatocyte cell cycle [citron kinase]
Title: Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G29083 (e-PCR)
- UniSTS:47377

D12Wox25 (e-PCR)
- UniSTS:518420

RH131289 (e-PCR)
- UniSTS:214572

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in generation of neurons	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density protein 95 clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin polymerization or depolymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glutamatergic postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: citron rho-interacting kinase

Names: citron (rho-interacting, serine/threonine kinase 21); citron Rho-interacting kinase; citron kinase; citron-K kinase; postsynaptic density protein (citron); rho-interacting, serine/threonine-protein kinase 21

NP_001025082.1

EC 2.7.11.1

XP_006249531.1

EC 2.7.11.1

XP_006249533.1

EC 2.7.11.1

XP_006249534.1

EC 2.7.11.1

XP_008767491.1

EC 2.7.11.1

XP_038945746.1

EC 2.7.11.1

XP_038945747.1

EC 2.7.11.1

XP_038945748.1

EC 2.7.11.1

XP_038945749.1

EC 2.7.11.1

XP_038945750.1

EC 2.7.11.1

XP_038945751.1

EC 2.7.11.1

XP_038945752.1

EC 2.7.11.1

XP_038945753.1

EC 2.7.11.1

XP_038945754.1

EC 2.7.11.1

XP_038945757.1

EC 2.7.11.1

XP_038945758.1

EC 2.7.11.1

XP_038945759.1

EC 2.7.11.1

XP_038945760.1

EC 2.7.11.1

XP_038945762.1

EC 2.7.11.1

XP_038945763.1

EC 2.7.11.1

XP_038945764.1

EC 2.7.11.1

XP_063127775.1

EC 2.7.11.1

XP_063127776.1

EC 2.7.11.1

XP_063127777.1

EC 2.7.11.1

XP_063127779.1

EC 2.7.11.1

XP_063127781.1

EC 2.7.11.1

XP_063127782.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029911.1 → NP_001025082.1 citron rho-interacting kinase

See identical proteins and their annotated locations for NP_001025082.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

A0A0G2JWA9, E9PSL7, Q9QX19

UniProtKB/TrEMBL

A0A8L2QNW2

Related

ENSRNOP00000069808.1, ENSRNOT00000086716.3

Conserved Domains (5) summary

smart00036
Location:1619 → 1915

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1470 → 1589

PH; PH domain

cd20814
Location:1385 → 1440

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

46263881..46425642 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089826.2 → XP_038945754.1 citron rho-interacting kinase isoform X15

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1577 → 1873

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:480 → 1282

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1428 → 1547

PH; PH domain

cd20814
Location:1343 → 1398

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089825.2 → XP_038945753.1 citron rho-interacting kinase isoform X14

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1577 → 1873

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:480 → 1282

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1428 → 1547

PH; PH domain

cd20814
Location:1343 → 1398

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089824.2 → XP_038945752.1 citron rho-interacting kinase isoform X13

UniProtKB/TrEMBL

A0A8I5YCF2, A0A8L2QNW2

Related

ENSRNOP00000077575.1, ENSRNOT00000118447.2

Conserved Domains (5) summary

smart00036
Location:1592 → 1888

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:480 → 1284

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1443 → 1562

PH; PH domain

cd20814
Location:1358 → 1413

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_006249472.5 → XP_006249534.1 citron rho-interacting kinase isoform X12

See identical proteins and their annotated locations for XP_006249534.1

UniProtKB/Swiss-Prot

A0A0G2JWA9, E9PSL7, Q9QX19

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1619 → 1915

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1470 → 1589

PH; PH domain

cd20814
Location:1385 → 1440

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_006249471.5 → XP_006249533.1 citron rho-interacting kinase isoform X11

UniProtKB/TrEMBL

A0A8L2QNW2, A0A8L2QQI1

Conserved Domains (5) summary

smart00036
Location:1634 → 1930

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 359

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:1404 → 1452

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam10174
Location:567 → 1402

Cast; RIM-binding protein of the cytomatrix active zone
XM_006249469.5 → XP_006249531.1 citron rho-interacting kinase isoform X7

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1649 → 1945

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 359

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:1404 → 1452

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam10174
Location:557 → 1402

Cast; RIM-binding protein of the cytomatrix active zone
XM_008769269.4 → XP_008767491.1 citron rho-interacting kinase isoform X6

See identical proteins and their annotated locations for XP_008767491.1

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1649 → 1945

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:97 → 359

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:1404 → 1452

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam10174
Location:557 → 1402

Cast; RIM-binding protein of the cytomatrix active zone
XM_039089823.2 → XP_038945751.1 citron rho-interacting kinase isoform X10

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1636 → 1932

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1321

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1472 → 1591

PH; PH domain

cd20814
Location:1387 → 1442

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_063271707.1 → XP_063127777.1 citron rho-interacting kinase isoform X9

UniProtKB/TrEMBL

A0A8L2QNW2
XM_063271706.1 → XP_063127776.1 citron rho-interacting kinase isoform X8

UniProtKB/TrEMBL

A0A8L2QNW2

Related

ENSRNOP00000053869.4, ENSRNOT00000057036.4
XM_063271705.1 → XP_063127775.1 citron rho-interacting kinase isoform X5

UniProtKB/TrEMBL

A0A8L2QNW2
XM_039089821.2 → XP_038945749.1 citron rho-interacting kinase isoform X3

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1663 → 1959

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1348

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1499 → 1618

PH; PH domain

cd20814
Location:1414 → 1469

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089822.2 → XP_038945750.1 citron rho-interacting kinase isoform X4

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1663 → 1959

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1363

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1514 → 1633

PH; PH domain

cd20814
Location:1429 → 1484

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089820.2 → XP_038945748.1 citron rho-interacting kinase isoform X2

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1678 → 1974

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1363

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1514 → 1633

PH; PH domain

cd20814
Location:1429 → 1484

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089818.2 → XP_038945746.1 citron rho-interacting kinase isoform X1

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1678 → 1974

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1363

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1514 → 1633

PH; PH domain

cd20814
Location:1429 → 1484

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089819.2 → XP_038945747.1 citron rho-interacting kinase isoform X1

UniProtKB/TrEMBL

A0A8L2QNW2

Conserved Domains (5) summary

smart00036
Location:1678 → 1974

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:472 → 1363

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

pfam00169
Location:1514 → 1633

PH; PH domain

cd20814
Location:1429 → 1484

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089830.2 → XP_038945758.1 citron rho-interacting kinase isoform X16

Conserved Domains (5) summary

PTZ00449
Location:1545 → 1636

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1233 → 1529

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:27 → 918

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1069 → 1188

PH; PH domain

cd20814
Location:984 → 1039

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089829.2 → XP_038945757.1 citron rho-interacting kinase isoform X16

Conserved Domains (5) summary

PTZ00449
Location:1545 → 1636

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1233 → 1529

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:27 → 918

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1069 → 1188

PH; PH domain

cd20814
Location:984 → 1039

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_063271711.1 → XP_063127781.1 citron rho-interacting kinase isoform X19
XM_039089831.2 → XP_038945759.1 citron rho-interacting kinase isoform X17

Conserved Domains (5) summary

PTZ00449
Location:1525 → 1616

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1213 → 1509

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:7 → 898

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1049 → 1168

PH; PH domain

cd20814
Location:964 → 1019

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_063271709.1 → XP_063127779.1 citron rho-interacting kinase isoform X18
XM_039089832.2 → XP_038945760.1 citron rho-interacting kinase isoform X18

Conserved Domains (5) summary

PTZ00449
Location:1524 → 1615

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:1212 → 1508

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

COG1196
Location:6 → 897

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00169
Location:1048 → 1167

PH; PH domain

cd20814
Location:963 → 1018

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089835.2 → XP_038945763.1 citron rho-interacting kinase isoform X21

Conserved Domains (5) summary

PTZ00449
Location:1176 → 1267

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00036
Location:864 → 1160

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

TIGR04523
Location:14 → 541

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam00169
Location:700 → 819

PH; PH domain

cd20814
Location:615 → 670

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_063271712.1 → XP_063127782.1 citron rho-interacting kinase isoform X23

UniProtKB/TrEMBL

A6J1R9
XM_039089834.2 → XP_038945762.1 citron rho-interacting kinase isoform X20

Conserved Domains (3) summary

COG1196
Location:472 → 1363

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

cd20814
Location:1429 → 1484

CRIK; protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins
XM_039089836.2 → XP_038945764.1 citron rho-interacting kinase isoform X22

Conserved Domains (2) summary

COG1196
Location:472 → 1225

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd05601
Location:96 → 421

STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_031790.1: Suppressed sequence

Description

NM_031790.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.