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    Kpna4 karyopherin subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361959, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Kpna4provided by RGD
    Official Full Name
    karyopherin subunit alpha 4provided by RGD
    Primary source
    RGD:1311483
    See related
    EnsemblRapid:ENSRNOG00000010768 AllianceGenome:RGD:1311483
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    importin
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of with a positive effect on dopamine secretion and gene expression. Predicted to act upstream of or within protein import into nucleus and response to hydrogen peroxide. Predicted to be located in male germ cell nucleus and nuclear membrane. Predicted to be part of NLS-dependent protein nuclear import complex and nuclear pore. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 566.5), Heart (RPKM 427.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kpna4 in Genome Data Viewer
    Location:
    2q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (155635679..155691056, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (153319380..153381085, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (165684345..165739874, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene structural maintenance of chromosomes 4 Neighboring gene microRNA 16 Neighboring gene tripartite motif-containing 59 Neighboring gene small Cajal body-specific RNA 7 Neighboring gene guanine nucleotide exchange factor MSS4-like Neighboring gene TOX high mobility group box family member 3 like 1 Neighboring gene uncharacterized LOC120100842

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The nuclear import factor importin α4 can protect against oxidative stress. Young JC, et al. Biochim Biophys Acta, 2013 Oct. PMID 23773962
    2. Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus. Pradeepa MM, et al. Mol Cell Biol, 2008 Jul. PMID 17682055, Free PMC Article
    3. Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth. Plant KE, et al. Pharmacogenet Genomics, 2006 Sep. PMID 16906019
    4. Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. Sakakida Y, et al. J Biol Chem, 2005 Apr 8. PMID 15689618
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A detailed analysis to characterize the molecular components underlying the nuclear translocation of TP2, was carried out.
      Title: Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NLS-bearing protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit alpha-3
    Names
    importin subunit alpha-4
    karyopherin (importin) alpha 4
    karyopherin alpha 4 (importin alpha 3)
    predicted role in nuclear import

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014793.1 → NP_001014793.1  importin subunit alpha-3

      See identical proteins and their annotated locations for NP_001014793.1

      Status: PROVISIONAL

      Source sequence(s)
      AY779028
      UniProtKB/TrEMBL
      F7FQB8, Q56R17
      Related
      ENSRNOP00000100890.1, ENSRNOT00000123454.1
      Conserved Domains (2) summary
      COG5064
      Location:11 → 513
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:279 → 311
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      155635679..155691056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102632.2 → XP_038958560.1  importin subunit alpha-3 isoform X1

      Related
      ENSRNOP00000109492.1, ENSRNOT00000163005.1
      Conserved Domains (2) summary
      COG5064
      Location:11 → 459
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:279 → 311
      ARM; armadillo repeat [structural motif]

    RNA

    1. XR_010063626.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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