Khk ketohexokinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Khkprovided by RGD
Official Full Name: ketohexokinaseprovided by RGD
Primary source: RGD:2966
See related: EnsemblRapid:ENSRNOG00000008047 AllianceGenome:RGD:2966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KETHPRO
Summary: Enables ketohexokinase activity. Involved in several processes, including response to hexose; response to insulin; and response to sucrose. Predicted to be located in nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1105.1) and Liver (RPKM 877.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (31165246..31175779, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25445298..25455834, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26810577..26821013, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Liver expression of the enzyme fructokinase, controlling fructose metabolism, was markedly induced by fructose ingestion in female, but not in male rats.
Title: Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose.
Atorvastatin decreased the expression of fructokinase in livers of fructose-supplemented rats, reducing the metabolic burden on the liver that is imposed by continuous fructose ingestion.
Title: Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment.
The present study provides information on the activity of Fructokinase in islets relative to that in other tissues and on the respective contribution of insulin-producing B cells and non-B islet cells.
Title: Fructokinase activity in rat liver, ileum, parotid gland, pancreas, pancreatic islet, B and non-B islet cell homogenates.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables fructose binding	IEA Inferred from Electronic Annotation more info
enables fructose binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ketohexokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketohexokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ketohexokinase activity	IEA Inferred from Electronic Annotation more info
enables ketohexokinase activity	ISO Inferred from Sequence Orthology more info
enables ketohexokinase activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in fructose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	ISO Inferred from Sequence Orthology more info
involved_in fructose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fructose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to fructose	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to sucrose	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to sucrose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to zinc ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ketohexokinase

Names: hepatic fructokinase

NP_114061.1

EC 2.7.1.3

XP_006239852.1

EC 2.7.1.3

XP_017449536.1

EC 2.7.1.3

XP_017449537.1

EC 2.7.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433234.1 → NP_001420163.1 ketohexokinase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001433235.1 → NP_001420164.1 ketohexokinase isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HAA9
NM_031855.4 → NP_114061.1 ketohexokinase isoform 1

See identical proteins and their annotated locations for NP_114061.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P97550, P97551, Q02974

UniProtKB/TrEMBL

A0A8L2QMK2, A6HAB0

Related

ENSRNOP00000046296.5, ENSRNOT00000043572.5

Conserved Domains (1) summary

cd01939
Location:5 → 295

Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

31165246..31175779 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594047.2 → XP_017449536.1 ketohexokinase isoform X2

Conserved Domains (1) summary

cd01939
Location:5 → 250

Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
XM_006239790.4 → XP_006239852.1 ketohexokinase isoform X1

Related

ENSRNOP00000095511.1, ENSRNOT00000114876.2

Conserved Domains (1) summary

cd01939
Location:5 → 295

Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
XM_017594048.2 → XP_017449537.1 ketohexokinase isoform X3

UniProtKB/TrEMBL

A0A8I6G7X9

Related

ENSRNOP00000081407.1, ENSRNOT00000104499.2