Hspb8 heat shock protein family B (small) member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hspb8provided by RGD
Full Name: heat shock protein family B (small) member 8provided by RGD
Primary source: RGD:71003
See related: EnsemblRapid:ENSRNOG00000022392 AllianceGenome:RGD:71003
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cryac; Hsp22
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein and positive regulation of aggrephagy. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and autosomal dominant distal hereditary motor neuronopathy 2. Orthologous to human HSPB8 (heat shock protein family B (small) member 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 829.9), Muscle (RPKM 758.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (45835899..45866449)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (40176405..40205002)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (45905371..45920014)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative Stress Mediated By Spinal AMPK/PGC-1alpha Pathway in Male Rats.
Title: Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative Stress Mediated By Spinal AMPK/PGC-1α Pathway in Male Rats.
DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy.
Title: DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy.
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1alpha signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Title: Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
HSP22 (HSPB8) positively regulates PGF2alpha-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts.
Title: HSP22 (HSPB8) positively regulates PGF2α-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts.
HSPB8 over-expression noticeably prevented blood-brain barrier disruption after cerebral ischemia/reperfusion injury... and this protective role was, at least in part, mediated through autophagy
Title: HSPB8 over-expression prevents disruption of blood-brain barrier by promoting autophagic flux after cerebral ischemia/reperfusion injury.
Our study demonstrated that HSPB8 is involved in the high glucose-induced autophagy under the in vivo and in vitro conditions and critically participated in the autophagosome-lysosome fusion during the autophagy flux.
Title: HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons.
High-level expression of HspB8 was critical for maintaining differentiation potential of dental pulp stem cells.
Title: Downregulation of heat shock protein B8 decreases osteogenic differentiation potential of dental pulp stem cells during in vitro proliferation.
HSPB8 and BAG3 are highly expressed during the synthetic phase of myometrial differentiation marked by initiation of uterine distension and myometrial hypertrophy.
Title: HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy.
Changes were observed in small heat shock proteins HSPB1, HSPB5 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats
Title: Changes in small heat shock proteins HSPB1, HSPB5 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats.
chaperone-like activity of HspB8
Title: The chaperone-like activity of rat HspB8/Hsp22 and dynamic molecular transition related to oligomeric architectures in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143808 (e-PCR)
- UniSTS:233054

RH134545 (e-PCR)
- UniSTS:217825

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
NOT enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aggrephagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein folding chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock protein beta-8

Names: alpha-crystallin C chain; crystallin, alpha C; heat shock 22kDa protein 8; heat shock protein 8; heat shock protein B8; small stress protein-like protein HSP22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053612.2 → NP_446064.1 heat shock protein beta-8

Status: PROVISIONAL

Source sequence(s)

BC061748

UniProtKB/Swiss-Prot

Q9EPX0

UniProtKB/TrEMBL

A6J1Q6

Related

ENSRNOP00000033432.3, ENSRNOT00000039275.5

Conserved Domains (1) summary

cd06480
Location:80 → 170

ACD_HspB8_like; Alpha-crystallin domain (ACD) found in mammalian 21.6 KDa small heat shock protein (sHsp) HspB8, also denoted as Hsp22 in humans, and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

45835899..45866449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089000.2 → XP_038944928.1 heat shock protein beta-8 isoform X1

UniProtKB/TrEMBL

A6J1Q5

Conserved Domains (1) summary

cl00175
Location:80 → 145

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.