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    Tpst1 tyrosylprotein sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288617, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tpst1provided by RGD
    Official Full Name
    tyrosylprotein sulfotransferase 1provided by RGD
    Primary source
    RGD:1308473
    See related
    EnsemblRapid:ENSRNOG00000000900 AllianceGenome:RGD:1308473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity and protein-tyrosine sulfotransferase activity. Predicted to be involved in post-translational protein modification. Predicted to act upstream of or within peptidyl-tyrosine sulfation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi lumen and trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 120.7), Testes (RPKM 106.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpst1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32180688..32247478, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26544536..26605706, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30045753..30112377, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene RAB guanine nucleotide exchange factor 1 Neighboring gene potassium channel tetramerization domain containing 7 Neighboring gene CGRP receptor component Neighboring gene small nucleolar RNA SNORA17 Neighboring gene argininosuccinate lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1. Tanaka S, et al. Sci Rep, 2017 Aug 18. PMID 28821720, Free PMC Article
    2. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Ouyang Yb, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501187, Free PMC Article
    3. Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody. Hoffhines AJ, et al. J Biol Chem, 2006 Dec 8. PMID 17046811, Free PMC Article
    4. Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment. Goettsch S, et al. J Mol Biol, 2006 Aug 18. PMID 16859706
    5. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, et al. Anticancer Res, 2016 Jul. PMID 27354594

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125193

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-tyrosine sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-tyrosine sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-tyrosine sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine sulfotransferase 1
    Names
    TPST-1
    NP_001011903.2
    XP_006249296.1
    XP_063127234.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011903.2 → NP_001011903.2  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_001011903.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105826
      UniProtKB/Swiss-Prot
      Q3KR92
      UniProtKB/TrEMBL
      A6J0M9, Q6AYS9
      Related
      ENSRNOP00000060104.3, ENSRNOT00000065868.3
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32180688..32247478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271164.1 → XP_063127234.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3KR92
      UniProtKB/TrEMBL
      A6J0M9, Q6AYS9

    2. XM_006249234.4 → XP_006249296.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QSG0, Q6AYS9
      Related
      ENSRNOP00000001200.5, ENSRNOT00000001200.7
      Conserved Domains (1) summary
      pfam13469
      Location:72 → 261
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KR92.1 GenPept UniProtKB/Swiss-Prot:Q3KR92

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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