Kif20a kinesin family member 20A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif20aprovided by RGD
Official Full Name: kinesin family member 20Aprovided by RGD
Primary source: RGD:1307695
See related: EnsemblRapid:ENSRNOG00000024428 AllianceGenome:RGD:1307695
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Predicted to be located in several cellular components, including intercellular bridge; midbody; and spindle. Human ortholog(s) of this gene implicated in restrictive cardiomyopathy. Orthologous to human KIF20A (kinesin family member 20A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 226.1), Spleen (RPKM 134.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (26504422..26512908)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (26230294..26238780)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (27424328..27432814)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that coupling between actin and microtubule cytoskeletons driven by Myosin II and KIF20A ensures the spatial coordination between RAB6-positive vesicles fission from Golgi/trans-Golgi network membranes and their exit along microtubules.
Title: Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131509 (e-PCR)
- UniSTS:214792

RH132745 (e-PCR)
- UniSTS:216028

RH127370 (e-PCR)
- UniSTS:210680

RH140853 (e-PCR)
- UniSTS:210680

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in midbody abscission	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF20A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108426.2 → NP_001101896.1 kinesin-like protein KIF20A

See identical proteins and their annotated locations for NP_001101896.1

Status: PROVISIONAL

Source sequence(s)

BC161953

UniProtKB/TrEMBL

A6J2V3, B1WC01, F7F7A1

Related

ENSRNOP00000037441.4, ENSRNOT00000033784.6

Conserved Domains (5) summary

cd01368
Location:62 → 504

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:69 → 505

Kinesin; Kinesin motor domain

pfam10267
Location:637 → 754

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

cd16269
Location:620 → 631

GBP_C; coiled coil [structural motif]

cl20817
Location:539 → 651

GBP_C; Guanylate-binding protein, C-terminal domain