Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrg3provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit gamma 3provided by RGD
Primary source: RGD:621735
See related: EnsemblRapid:ENSRNOG00000014862 AllianceGenome:RGD:621735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA-A receptor activity and GABA-gated chloride ion channel activity. Involved in response to xenobiotic stimulus. Predicted to be located in microtubule cytoskeleton; nucleolus; and plasma membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in several cellular components, including GABA-ergic synapse; dendrite membrane; and synaptic membrane. Orthologous to human GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 41.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (116763332..117386770, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (107627450..108247483, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (112158525..112812267, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137869 (e-PCR)
- UniSTS:219956

D1Rat345 (e-PCR), detects polymorphism
- UniSTS:227143

Gabrg3 (e-PCR), detects polymorphism
- UniSTS:525656

AU048805 (e-PCR)
- UniSTS:145255

BF391052 (e-PCR)
- UniSTS:249736

AU048232 (e-PCR)
- UniSTS:109740

BM387166 (e-PCR)
- UniSTS:261316

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit gamma-3

Names: GABA(A) receptor subunit gamma-3; GABA-alpha receptor gamma-3 subunit; GABAAR subunit gamma-3; gamma-aminobutyric acid (GABA) A receptor, gamma 3; gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3; gamma-aminobutyric acid A receptor, gamma 3; gamma-aminobutyric acid type A receptor gamma 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024370.3 → NP_077346.3 gamma-aminobutyric acid receptor subunit gamma-3 precursor

See identical proteins and their annotated locations for NP_077346.3

Status: VALIDATED

Source sequence(s)

M81142, X63324

UniProtKB/Swiss-Prot

P28473

UniProtKB/TrEMBL

A0A0A0MXX6, A6KD36

Related

ENSRNOP00000076184.1, ENSRNOT00000093339.3

Conserved Domains (3) summary

TIGR00860
Location:50 → 464

LIC; Cation transporter family protein

pfam02931
Location:48 → 253

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:260 → 461

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region