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    Slc25a15 solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 [ Mus musculus (house mouse) ]

    Gene ID: 18408, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a15provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15provided by MGI
    Primary source
    MGI:MGI:1342274
    See related
    Ensembl:ENSMUSG00000031482 AllianceGenome:MGI:1342274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ornt1; D630044L02Rik
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity and antiporter activity. Predicted to be involved in L-arginine transmembrane transport; L-lysine transmembrane transport; and mitochondrial L-ornithine transmembrane transport. Located in mitochondrial inner membrane. Is expressed in liver; metanephros; midgut; and retina. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; citrullinemia; and ornithine translocase deficiency. Orthologous to human SLC25A15 (solute carrier family 25 member 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 48.0), large intestine adult (RPKM 23.7) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a15 in Genome Data Viewer
    Location:
    8 A2; 8 11.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22865566..22888637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22375550..22398621, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene thrombospondin, type I, domain 1 Neighboring gene transmembrane phosphatase with tensin homology Neighboring gene predicted gene, 46035 Neighboring gene RIKEN cDNA 1810012K16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6625 Neighboring gene predicted gene, 53406 Neighboring gene PDZ and LIM domain protein 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Camacho JA, et al. Nat Genet, 1999 Jun. PMID 10369256
    2. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Calvo SE, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19372376, Free PMC Article
    3. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~55%.
      Title: Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-lysine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-ornithine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-ornithine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-lysine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ornithine transporter 1
    Names
    ornithine transporter, mitochondrial 1
    solute carrier family 25 member 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358971.1 → NP_001345900.1  mitochondrial ornithine transporter 1

      Status: VALIDATED

      Source sequence(s)
      AC140326
      Consensus CDS
      CCDS22175.1
      UniProtKB/Swiss-Prot
      Q9WVD5
      UniProtKB/TrEMBL
      Q543E2
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 296
      Mito_carr; Mitochondrial carrier protein

    2. NM_181325.4 → NP_851842.1  mitochondrial ornithine transporter 1

      See identical proteins and their annotated locations for NP_851842.1

      Status: VALIDATED

      Source sequence(s)
      AK052758, AK142223, AK145966, CJ172337, DV644804
      Consensus CDS
      CCDS22175.1
      UniProtKB/Swiss-Prot
      Q9WVD5
      UniProtKB/TrEMBL
      Q543E2
      Related
      ENSMUSP00000033871.7, ENSMUST00000033871.8
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 296
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22865566..22888637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVD5.1 GenPept UniProtKB/Swiss-Prot:Q9WVD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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