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    Lmo1 LIM domain only 1 [ Mus musculus (house mouse) ]

    Gene ID: 109594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmo1provided by MGI
    Official Full Name
    LIM domain only 1provided by MGI
    Primary source
    MGI:MGI:102812
    See related
    Ensembl:ENSMUSG00000036111 AllianceGenome:MGI:102812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttg1; Rbtn1; Rbtn-1
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and transcription coactivator activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of T cell homeostatic proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human LMO1 (LIM domain only 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 28.1), whole brain E14.5 (RPKM 23.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmo1 in Genome Data Viewer
    Location:
    7 E3; 7 57.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108737776..108774356, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109138565..109175207, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TUB bipartite transcription factor Neighboring gene RIC3 acetylcholine receptor chaperone Neighboring gene predicted gene, 25450 Neighboring gene STARR-seq mESC enhancer starr_19793 Neighboring gene predicted gene 44781 Neighboring gene STARR-seq mESC enhancer starr_19794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:116409223-116409433 Neighboring gene predicted gene, 32563 Neighboring gene predicted gene, 51463

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system. Greenberg JM, et al. Nature, 1990 Mar 8. PMID 2106626
    2. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. McGuire EA, et al. Mol Cell Biol, 1992 Sep. PMID 1508213, Free PMC Article
    3. scid Thymocytes with TCRbeta gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes. Chervinsky DS, et al. Cancer Res, 2001 Sep 1. PMID 11522630
    4. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. McGuire EA, et al. Mol Cell Biol, 1989 May. PMID 2501659, Free PMC Article
    5. Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia. Oram SH, et al. Leukemia, 2013 Jun. PMID 23302769, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCL-LMO1 upregulated a stem cell gene signature in DN3 thymocytes.
      Title: SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.
    2. Loss of Lmo1 repression may be one of the causes accounting for the phenotypic differences identified between the Arx((GCG)7)and Arx(432-455dup24) mouse models.
      Title: Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.
    3. SCL, LMO1, and Notch1 gain of function, together with an active pre-T-cell antigen receptor, might represent the minimum set of complementing events for the transformation of susceptible thymocytes into cancer cells
      Title: Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
    4. Lmo1 takes part in a Hox paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning
      Title: Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.
    5. Results suggest that all four members of the LIM-only family -- LMO1, 2, 3, and 4 -- are important regulators of distinct developmental pathways.
      Title: Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of T cell homeostatic proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhombotin-1
    Names
    LIM domain only protein 1
    LIM only 1
    T-cell translocation protein 1
    cysteine-rich protein TTG-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302205.2 → NP_001289134.1  rhombotin-1 isoform 2

      See identical proteins and their annotated locations for NP_001289134.1

      Status: VALIDATED

      Source sequence(s)
      AC147221
      Consensus CDS
      CCDS85378.1
      UniProtKB/TrEMBL
      A0A140LIB4
      Related
      ENSMUSP00000146752.2, ENSMUST00000207178.2
      Conserved Domains (2) summary
      cd09388
      Location:23 → 77
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:87 → 141
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    2. NM_001302206.2 → NP_001289135.1  rhombotin-1 isoform 3

      See identical proteins and their annotated locations for NP_001289135.1

      Status: VALIDATED

      Source sequence(s)
      AC147221
      Consensus CDS
      CCDS85377.1
      UniProtKB/TrEMBL
      A0A140LHX4
      Related
      ENSMUSP00000146588.2, ENSMUST00000208136.2
      Conserved Domains (2) summary
      cd09388
      Location:13 → 67
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:77 → 131
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    3. NM_001382564.1 → NP_001369493.1  rhombotin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC147221
      UniProtKB/Swiss-Prot
      Q924W9
      UniProtKB/TrEMBL
      Q3UZX1
      Conserved Domains (2) summary
      cd09388
      Location:24 → 78
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:88 → 142
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    4. NM_057173.4 → NP_476514.1  rhombotin-1 isoform 1

      See identical proteins and their annotated locations for NP_476514.1

      Status: VALIDATED

      Source sequence(s)
      AC147221
      Consensus CDS
      CCDS40080.1
      UniProtKB/Swiss-Prot
      Q924W9
      UniProtKB/TrEMBL
      Q3UZX1
      Related
      ENSMUSP00000037079.8, ENSMUST00000036992.9
      Conserved Domains (2) summary
      cd09388
      Location:24 → 78
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:88 → 142
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      108737776..108774356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924W9.1 GenPept UniProtKB/Swiss-Prot:Q924W9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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