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    ACOT1 acyl-CoA thioesterase 1 [ Homo sapiens (human) ]

    Gene ID: 641371, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ACOT1provided by HGNC
    Official Full Name
    acyl-CoA thioesterase 1provided by HGNC
    Primary source
    HGNC:HGNC:33128
    See related
    Ensembl:ENSG00000184227 MIM:614313; AllianceGenome:HGNC:33128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACH2; CTE-1; LACH2
    Summary
    Enables fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in fat (RPKM 27.2), liver (RPKM 24.9) and 24 other tissues See more
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    Genomic context

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    See ACOT1 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73490933..73543796)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (67698892..67751306)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74003847..74010500)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73743236-73743736 Neighboring gene NUMB endocytic adaptor protein Neighboring gene NANOG hESC enhancer GRCh37_chr14:73864401-73864904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5909 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:73926115-73926648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:73925581-73926114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5910 Neighboring gene uncharacterized LOC101928143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8699 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73956718-73957623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73958602-73959102 Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1 Neighboring gene uncharacterized LOC124903344 Neighboring gene NANOG hESC enhancer GRCh37_chr14:74020474-74020986 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74033223-74033740 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:74034134-74035333 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8703 Neighboring gene tRNA-Lys (TTT) 14-1 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 1 Neighboring gene acyl-CoA thioesterase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver. Cavalli M, et al. OMICS, 2021 Oct. PMID 34520261, Free PMC Article
    2. ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma. Wang F, et al. Hum Pathol, 2018 Jul. PMID 29555575
    3. Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication. St Clair LA, et al. Viruses, 2022 Jan 25. PMID 35215835, Free PMC Article
    4. Pangenomic analysis of Chinese gastric cancer. Yu Y, et al. Nat Commun, 2022 Sep 15. PMID 36109518, Free PMC Article
    5. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genes ACOT1, GSTM1, SIGLEC14 and UGT2B17 are identified as highly absent genes in gastric cancer population.
      Title: Pangenomic analysis of Chinese gastric cancer.
    2. Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
      Title: Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.
    3. The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver.
      Title: The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver.
    4. that increased expression of ACOT1 is correlated with pivotal clinicopathological parameters and poor prognosis in gastric adenocarcinoma through increased expression of the potential tumor-promoting protein GLI3
      Title: ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase 1
    Names
    CTE-I
    CTE-Ib
    inducible cytosolic acyl-coenzyme A thioester hydrolase
    long chain acyl-CoA hydrolase
    long chain acyl-CoA thioester hydrolase
    palmitoyl-coenzyme A thioesterase
    NP_001032238.1
    XP_016877078.1
    XP_016877079.1
    XP_054232550.1
    XP_054232551.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037161.2 → NP_001032238.1  acyl-coenzyme A thioesterase 1

      See identical proteins and their annotated locations for NP_001032238.1

      Status: VALIDATED

      Source sequence(s)
      AC005225, DQ082754
      Consensus CDS
      CCDS32117.1
      UniProtKB/Swiss-Prot
      A1L173, Q3I5F9, Q86TX2
      UniProtKB/TrEMBL
      A1L172, B4DV16, E9KL42
      Related
      ENSP00000311224.4, ENST00000311148.9
      Conserved Domains (3) summary
      pfam08840
      Location:204 → 412
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:16 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:138 → 252
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      73490933..73543796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021590.2 → XP_016877079.1  acyl-coenzyme A thioesterase 1 isoform X2

      Conserved Domains (1) summary
      pfam08840
      Location:81 → 289
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

    2. XM_017021589.2 → XP_016877078.1  acyl-coenzyme A thioesterase 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      67698892..67751306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376576.1 → XP_054232551.1  acyl-coenzyme A thioesterase 1 isoform X2

    2. XM_054376575.1 → XP_054232550.1  acyl-coenzyme A thioesterase 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86TX2.1 GenPept UniProtKB/Swiss-Prot:Q86TX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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