Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ormdl3provided by RGD
Official Full Name: ORMDL sphingolipid biosynthesis regulator 3provided by RGD
Primary source: RGD:1560577
See related: EnsemblRapid:ENSRNOG00000030445 AllianceGenome:RGD:1560577
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRRGT00183
Summary: Predicted to be involved in ceramide metabolic process; intracellular sphingolipid homeostasis; and sphingolipid biosynthetic process. Predicted to act upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and negative regulation of serine C-palmitoyltransferase activity. Predicted to be located in endoplasmic reticulum. Predicted to be part of serine palmitoyltransferase complex. Orthologous to human ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 282.5), Adrenal (RPKM 192.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (84086317..84092673, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (83590052..83596035, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (86545910..86554478, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137109 (e-PCR)
- UniSTS:219197

RH143569 (e-PCR)
- UniSTS:232815

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular sphingolipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of motor behavior	ISO Inferred from Sequence Orthology more info
involved_in myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ceramide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of serine C-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of sphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingomyelin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of sphingomyelin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of serine palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of serine palmitoyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of serine palmitoyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of serine palmitoyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ORM1-like protein 3

Names: ORM1-like 3; liver regeneration-related protein LRRGT00183

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413293.1 → NP_001400222.1 ORM1-like protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q6QI25

UniProtKB/TrEMBL

A0A0G2JSW1

Related

ENSRNOP00000046432.4, ENSRNOT00000049621.5
NM_001413294.1 → NP_001400223.1 ORM1-like protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q6QI25

UniProtKB/TrEMBL

A0A0G2JSW1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

84086317..84092673 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269423.1 → XP_063125493.1 ORM1-like protein 3 isoform X1

UniProtKB/Swiss-Prot

Q6QI25

UniProtKB/TrEMBL

A0A0G2JSW1
XM_063269422.1 → XP_063125492.1 ORM1-like protein 3 isoform X1

UniProtKB/Swiss-Prot

Q6QI25

UniProtKB/TrEMBL

A0A0G2JSW1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001047897.1: Suppressed sequence

Description

NM_001047897.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.