Wwc2 WW and C2 domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wwc2provided by RGD
Official Full Name: WW and C2 domain containing 2provided by RGD
Primary source: RGD:1559427
See related: EnsemblRapid:ENSRNOG00000013248 AllianceGenome:RGD:1559427
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559427
Summary: Predicted to enable kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including hippo signaling; negative regulation of hippo signaling; and negative regulation of organ growth. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC2 (WW and C2 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 189.5), Lung (RPKM 113.2) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 16q11

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (50991096..51154529)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (44258372..44421815)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (47368768..47533816)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

BF410396 (e-PCR)
- UniSTS:246791

BE107847 (e-PCR)
- UniSTS:247091

BF390151 (e-PCR)
- UniSTS:249395

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: protein WWC2

Names: WW, C2 and coiled-coil domain containing 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109111.1 → NP_001102581.1 protein WWC2

See identical proteins and their annotated locations for NP_001102581.1

Status: PROVISIONAL

Source sequence(s)

CH473995

UniProtKB/TrEMBL

A6JPK1, D4AEJ5

Related

ENSRNOP00000017966.4, ENSRNOT00000017966.7

Conserved Domains (5) summary

cd08680
Location:699 → 822

C2_Kibra; C2 domain found in Human protein Kibra

pfam00397
Location:12 → 41

WW; WW domain

pfam11068
Location:351 → 420

YlqD; YlqD protein

cl01720
Location:1095 → 1153

Phage_Nu1; Phage DNA packaging protein Nu1

cl19219
Location:283 → 385

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

50991096..51154529

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275643.1 → XP_063131713.1 protein WWC2 isoform X1

Related

ENSRNOP00000109755.1, ENSRNOT00000162186.1
XM_063275644.1 → XP_063131714.1 protein WWC2 isoform X2
XM_039094772.2 → XP_038950700.1 protein WWC2 isoform X3

Conserved Domains (3) summary

cd08680
Location:515 → 638

C2_Kibra; C2 domain found in Human protein Kibra

COG1196
Location:7 → 231

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd06503
Location:897 → 984

ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b